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008    061020t20072007flua     b    001 0 eng   
010      2006035219 
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020    9780849372728 
020    0849372720 
035    (OCoLC)74459862 
035    (Sirsi) i9780849372728 
040    DNLM/DLC|beng|cDLC|dBAKER|dNLM|dBTCTA|dYDXCP|dC#P|dMUQ
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042    pcc 
049    STJJ 
050 00 RA1220.3|b.B64 2007 
060 00 2007 F-245 
060 10 QV 602|bB671n 2007 
082 00 615.9|222 
092    615.9|bB671M 
100 1  Boelsterli, Urs A.,|d1948- 
245 10 Mechanistic toxicology :|bthe molecular basis of how 
       chemicals disrupt biological targets /|cUrs A. Boelsterli.
250    Second edition. 
264  1 Boca Raton :|bCRC Press,|c[2007] 
264  4 |c©2007 
300    399 pages :|billustrations ;|c25 cm 
336    text|btxt|2rdacontent 
337    unmediated|bn|2rdamedia 
338    volume|bnc|2rdacarrier 
504    Includes bibliographical references and index. 
505 0  Introduction -- Types of toxic responses -- Organ-
       selective toxicity -- Cellular transport and selective 
       accumulation of potentially toxic xenobiotics -- 
       Bioactivation of xenobiotics to reactive metabolites -- 
       Xenobiotic-induced oxidative stress: cell injury, 
       signaling, and gene regulation -- Disruption of cellular 
       calcium homeostasis -- Mechanisms of necrotic and 
       apoptotic cell death -- Impairment of cell proliferation 
       and tissue repair -- Covalent binding of reactive 
       metabolites to cellular macromolecules -- Immune 
       mechanisms -- Cytokine-mediated toxicity -- Specific 
       inactivation of enzymes and other proteins -- Interactions
       of xenobiotics with ion transporters -- Nuclear receptor-
       mediated toxicity -- Activation or disruption of cellular 
       signal transduction by xenobiotics -- Disruption of 
       mitochondrial function and mitochondria-mediated toxicity 
       -- Novel mechanisms derived from systems toxicology. 
650  0 Molecular toxicology. 
650 12 Toxicology|xmethods. 
650 22 Molecular Biology|xmethods. 
650 22 Signal Transduction. 
650 22 Xenobiotics|xpharmacokinetics. 
650 22 Xenobiotics|xtoxicity. 
856 42 |3Publisher description|uhttp://www.loc.gov/catdir/
       enhancements/fy0703/2006035219-d.html 
938    Baker & Taylor|bBKTY|c69.95|d.00|i0849372720|n0006662430
       |sactive 
938    YBP Library Services|bYANK|n2478992 
994    01|bSTJ