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Author Boelsterli, Urs A., 1948-

Title Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets / Urs A. Boelsterli.

Publication Info. Boca Raton : CRC Press, [2007]


Location Call No. Status
 University of Saint Joseph: Pope Pius XII Library - Reference Material  PHARM QV 602 B671M 2007    In-Library Use Only
Edition Second edition.
Description 399 pages : illustrations ; 25 cm
Bibliography Includes bibliographical references and index.
Contents Introduction -- Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology.
Subject Molecular toxicology.
Toxicology -- methods.
Molecular Biology -- methods.
Signal Transduction.
Xenobiotics -- pharmacokinetics.
Xenobiotics -- toxicity.
ISBN 9780849372728
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