LEADER 00000cam  2200577Ii 4500 
001    on1041853297 
003    OCoLC 
005    20200515065719.0 
006    m     o  d         
007    cr cnu---unuuu 
008    180625s2018    enka    ob    001 0 eng d 
015    GBB8C0866|2bnb 
016 7  018922642|2Uk 
019    1042083361|a1058881607|a1086518033|a1105168708|a1105567576
020    9780128161432|q(electronic book) 
020    0128161434|q(electronic book) 
020    |z9780128161425 
020    |z0128161426 
035    (OCoLC)1041853297|z(OCoLC)1042083361|z(OCoLC)1058881607
       |z(OCoLC)1086518033|z(OCoLC)1105168708|z(OCoLC)1105567576 
037    9780128161432|bIngram Content Group 
040    N$T|beng|erda|epn|cN$T|dN$T|dOPELS|dEBLCP|dUAB|dYDX|dSTF
       |dMERER|dOCLCF|dCNCGM|dOCLCQ|dYDX|dOTZ|dNLE|dCOO|dSNK|dAU@
       |dUKMGB|dU3W|dLVT|dD6H|dLQU|dUHL|dOCLCO|dOCLCQ|dOCLCA
       |dOCLCQ|dOCLCA|dSTJ 
049    STJJ 
050  4 QP552.F5|bL59 2018 
072  7 SOC|x002020|2bisacsh 
082 04 573.4|223 
099    WORLD|aWIDE|aWEB|aE-BOOK|aSCIENCE 
100 1  Li, Xiaokun,|d1964-|eauthor. 
245 10 Fibroblast growth factors /|cXiaokun Li. 
264  1 London :|bAcademic Press ;|aBeijing L|bHigher Education 
       Press,|c[2018] 
300    1 online resource (xii, 571 pages) 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
504    Includes bibliographical references and index. 
505 0  Front Cover; Fibroblast Growth Factors; Fibroblast Growth 
       Factors; Copyright; Contents; Preface; Preface; 1 -- 
       Engineered Growth Factor; Engineered Growth Factors and 
       Cutaneous WoundHealing: Success and Possible Questions in 
       thePast 10 Years; 1. Introduction; 2. Is There a Need for 
       Exogenous Application of Growth Factors in Acute or 
       Chronic Wounds?; 3. Have Growth Factors Altered Clinical 
       Practice in the Past and Will They Alter It in the 
       Future?; 4. Do We Need a Special Delivery System for the 
       Growth Factors in Local Wound Healing? 
505 8  5. Is It Safe to Use Growth Factors to Promote Wound 
       Healing?6. Have All Problems Involved in Wound Healing 
       Been Solved With Growth Factor Application?; 7. Can 
       Perfect Wound Healing Be Achieved in Wounds Treated With 
       Growth Factors?; 8. How Great a Change in Healing Events 
       Would Require a Growth Factor to Become Clinically 
       Important?; 9. What Needs to Be Done to Include Growth 
       Factors in Clinical Practice Within the Next 5-10Years?; 
       References; 2 -- FGFs in Injury Repair and Regeneration 
505 8  Regulation of Autophagy and Ubiquitinated 
       ProteinAccumulation by bFGF Promotes FunctionalRecovery 
       and Neural Protection in a Rat Model ofSpinal Cord 
       Injury1. Introduction; 2. Materials and Methods; 2.1 
       Reagents and Antibodies; 2.2 Cell Culture; 2.3 Procedure 
       for Investigating an Animal Model of Spinal Cord Injury; 
       2.4 Locomotion Recovery Assessment; 2.5 Hematoxylin-Eosin 
       Staining and Nissl Staining; 2.6 Western Blot Analysis; 
       2.7 Immunofluorescence Staining; 2.8 Statistical Analysis;
       3. Results; 3.1 bFGF Decreases Motor Neuron Loss and 
       Improves Functional Recovery of SCI In Vivo 
505 8  3.2 The Protective Effect of bFGF Is Related to Inhibited 
       Autophagy in the SCI Model Mice3.3 Activation of PI3K/Akt/
       mTOR Signaling Pathways Is Involved in the Role of bFGF in
       SCI Recovery; 3.4 bFGF Improves Recovery After SCI by 
       Autophagic Clearance of Ubiquitinated Protein 
       Accumulation; 3.5 Combination With the Autophagy 
       Sensitizer Rapamycin Partially Abolishes the Protective 
       Effect of bFGF in SCI Model Rats; 3.6 Exogenous bFGF 
       Protects PC-12 Cells by Inhibition of Excessive Autophagy 
       In Vitro; 4. Discussion; The Antiscar Effects of bFGF on 
       Wound RepairIn Vitro and In Vivo; 1. Introduction 
505 8  2. Materials and Methods2.1 Ethics Statement; 2.2 Animal 
       Model; 2.3 Histological Examination and 
       Immunohistochemistry Staining; 2.4 Terminal 
       Deoxynucleotidyl Transferase-Mediated dUTP Nick-End 
       Labeling Staining; 2.5 Collagen I and Collagen III 
       Quantification; 2.6 Western Blot; 2.7 Fibroblasts Culture;
       2.8 Quantitative Real-Time PCR; 2.9 Statistical Analysis; 
       3. Results; 3.1 bFGF Accelerates Acute Wound Closure in 
       the Rat-Incised Injury Model; 3.2 bFGF Alleviates the Scar
       Formation in the Rabbit Ear Model; 3.3 Effect of bFGF on 
       Collagen I and Collagen III Synthesis 
520 8  Fibroblast Growth Factors presents research and results 
       from the leading global research group on FGF, providing 
       up-to-date and comprehensive coverage of the field. The 
       book describes the history, basic research and growth 
       engineering technology involved with FGFs, while also 
       introducing detailed research methods. It comprises eight 
       chapters that detail successes and problems in relation to
       wound healing of engineered growth factors and considers 
       injury repair and regeneration, non-mitogenic mutants, 
       structure modification, pathology, physiology, 
       pharmacology, development, FGF/FGFR inhibitors, 
       bioengineering, and new drug development. It will serve as
       a key reference book for researchers working on FGFs. 
588 0  Online resource; title from digital title page (viewed on 
       September 04, 2018). 
650  0 Fibroblast growth factors. 
650  2 Receptors, Fibroblast Growth Factor.|0(DNLM)D017468 
650  2 Fibroblast Growth Factor 2.|0(DNLM)D016222 
650  7 SOCIAL SCIENCE|xAnthropology|xPhysical.|2bisacsh 
650  7 Fibroblast growth factors.|2fast|0(OCoLC)fst00923668 
776 08 |iPrint version:|aLi, Xiaokun.|tFibroblast growth factors.
       |dLondon : Academic Press ; Beijing L Higher Education 
       Press, [2018]|z0128161426|z9780128161425
       |w(OCoLC)1020030154 
880 8  |6505-00|a3.4 Effect of bFGF on α-SMA and TGF-β1 
       Expression 
994    C0|bSTJ