| Edition |
Second edition / edited by Paul G. Pearson, Larry C. Wienkers. |
| Description |
1 online resource (xii, 694 pages) : illustrations, digital, HTML and PDF files. |
| Series |
Drugs and the pharmaceutical sciences ; 186 |
|
Drugs and the pharmaceutical sciences ; v. 186.
|
| Bibliography |
Includes bibliographical references and index. |
| Summary |
"This timely and expanded new edition is the definitive handbook for experienced drug metabolism and pharmaceutical scientists, as well as those new to the field. Written by internationally renowned authors, it provides integrated, comprehensive coverage of the fundamental aspects of drug metabolism and the practical applications that help guide researchers through key challenges in modern drug discovery and development." "The Second Edition covers the many recent scientific and technical advances in the field and is organized into four sections-ideal for use in undergraduate and graduate programs in Drug Metabolism and Clinical Pharmacology: fundamental aspects of drug metabolism; factors that affect drug metabolism; new enabling technologies to study drug metabolism; and applications of metabolism studies in drug development and drug discovery."--Jacket. |
| Note |
Description based on print version record. |
| Contents |
The Evolution of drug metabolism research -- Pharmacokinetics of drug metabolites -- Hepatic architecture : functional and subcellular correlates -- The cytochrome P450 oxidative system -- Transformation enzymes : oxidative; non-P450 -- UDP-glucuronosyltransferases -- Pharmacogenetics -- Inhibition of drug metabolizing enzymes -- The ontogeny of drug metabolizing enzymes/pediatric exclusivity -- Sites of extra hepatic metabolism, part I : Lung -- Sites of extra hepatic metabolism, part II : Gut -- Sites of extra hepatic metabolism, part III : Kidney -- Sites of extra hepatic metabolism, part IV : Brain -- LC-MS analysis in drug metabolism studies -- The practice of NMR spectroscopy in drug metabolism studies -- Applications of recombinant and purified human drug-metabolizing enzymes : an industrial perspective -- In vitro metabolism : subcellular fractions -- In vitro metabolism : hepatocytes -- Drug interaction studies in the drug development process : studies in vitro -- Enzyme induction studies in drug discovery & development -- Experimental characterization of cytochrome P450 mechanism based inhibition -- Clinical drug metabolism -- Minimizing metabolic activation in drug discovery -- Kinetic differences between generated and preformed metabolites : a dilemma in risk assessment -- The use of transgenic animals to study drug metabolism -- Preclinical pharmacokinetic models for drug discovery and development. |
| Note |
GMD: electronic resource. |
| Subject |
Drugs -- Metabolism -- Handbooks, manuals, etc.
|
|
Pharmaceutical Preparations -- metabolism.
|
| Added Author |
Pearson, Paul G. (Paul Gerard), 1960-
|
|
Wienkers, Larry C.
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