| Description |
xxi, 403 pages : illustrations ; 25 cm |
| Bibliography |
Includes bibliographical references and index. |
| Contents |
The role of pharmacokinetics and pharmacodynamics in the development of biotech drugs / Bernd Meibohm -- Pharmacokinetics of peptides and proteins / Lisa Tang, Bernd Meibohm -- Pharmacokinetics of monoclonal antibodies / Katharina Kuester, Charlotte Kloft -- Pharmacokinetics and pharmacodynamics of antisense oligonucleotides / Rosie Z. Yu, Richard S. Geary, Arthur A. Levin -- Pharmacokinetics of viral and non-viral gene delivery vectors / Martin Meyer, Gururaj Rao, Ke Ren, Jeffrey Hughes -- Bioanalytical methods used for pharmacokinetic evaluations of biotech macromolecule drugs : issues, assay approaches, and limitations / Jean W. Lee -- Limitations of noncompartmental pharmacokinetic analysis of biotech drugs / Arthur B. Straughn -- Bioequivalence of biologics / Jeffrey S. Barrett -- Biopharmaceutical challenges: pulmonary delivery of proteins and peptides / Kun Cheng, Ram I. Mahato -- Biopharmaceutical challenges : delivery of oligonucleotides / Lloyd G. Tillman, Gregory E. Hardee -- Custom-tailored pharmacokinetics and pharmacodynamics via chemical modifications of biotech drugs / Francesco M. Veronese, Paolo Caliceti -- Exposure-response relationships for therapeutic biologic products / Mohammad Tabrizi, Lorin K. Roskos -- Preclinical and clinical drug development of tasidotin, a depsi-pentapeptide oncolytic agent / Peter L. Bonate, Larry Arthaud, Katherine Stephenson -- Clinical drug development of cetuximab, a monoclonal antibody / Arno Nolting, Floyd E. Fox, Andreas Kovar -- Integration of pharmacokinetics and pharmacodynamics into the drug development of pegfilgrastim, a pegylated protein / Bing-Bing Yang. |
| Subject |
Pharmaceutical biotechnology.
|
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Pharmacokinetics.
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Drugs -- Physiological effect.
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Drug development.
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Pharmacokinetics.
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Biotechnology -- methods.
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Drug Design.
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Pharmaceutical Preparations -- metabolism.
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Pharmacology -- methods.
|
| Added Author |
Meibohm, Bernd.
|
| ISBN |
3527314083 alkaline paper |
|
9783527314089 alkaline paper |
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