| Description |
1 online resource (xiii, 694 pages) : illustrations (some color). |
|
text file PDF rda |
| Series |
Handbook of Experimental Pharmacology, 1865-0325 ; volume 224 |
|
Handbook of experimental pharmacology ; v. 224.
0171-2004
|
| Bibliography |
Includes bibliographical references and index. |
| Note |
Online resource; title from resource home page (SpringerLink, viewed April 19, 2016). |
| Contents |
Part 1: Physiology of HDL. Structure of HDL: particle subclasses and molecular components HDL biogenesis, remodeling, and catabolism -- Regulation of HDL genes: transcriptional, posttranscriptional, and posttranslational -- Cholesterol efflux and reverse cholesterol transport -- Functionality of HDL: antioxidation and detoxifying effects -- Signal transduction by HDL: agonists, receptors, and signaling cascades -- Part 2: Pathology of HDL. Epidemiology: disease associations and modulators of HDL-related biomarkers -- Beyond the genetics of HDL: why is HDL cholesterol inversely related to cardiovascular disease? -- Mouse models of disturbed HDL metabolism -- Dysfunctional HDL: from structure-function-relationships to biomarkers -- Part 3: Possible indications and target mechanisms of HDL therapy. HDL and atherothrombotic vascular disease -- HDLs, diabetes, and metabolic syndrome -- High-density lipoprotein: structural and functional changes under uremic conditions and the therapeutic consequences -- Impact of systemic inflammation and autoimmune diseases on apoA-I and HDL plasma levels and functions -- HDL in infectious diseases and sepsis -- High-density lipoproteins in stroke -- Therapeutic potential of HDL in cardioprotection and tissue repair -- Part 4: Treatments for dyslipidemias and dysfunction of HDL. HDL and lifestyle interventions -- Effects of established hypolipidemic drugs on HDL concentration, subclass distribution, and function -- Emerging small molecule drugs -- ApoA-I mimetics -- Antisense oligonucleotides, microRNAs, and antibodies. |
| Summary |
"In this Handbook of Experimental Pharmacology on "High Density Lipoproteins: from biological understanding to clinical exploitation" contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation"--Publisher's description. |
| Local Note |
SpringerLink Springer Nature Open Access eBooks |
| Language |
English. |
| Subject |
High density lipoproteins -- Physiological effect.
|
|
High density lipoproteins -- Pathophysiology.
|
|
High density lipoproteins -- Therapeutic use.
|
|
Lipoproteins, HDL -- physiology.
|
|
Biochemical engineering.
|
|
Energy industries & utilities.
|
|
Management of specific areas.
|
|
Manufacturing industries.
|
|
Medicine.
|
|
High density lipoproteins -- Pathophysiology.
(OCoLC)fst00956014
|
| Added Author |
Eckardstein, Arnold von, editor.
|
|
Kardassis, Dimitris, editor.
|
| Other Form: |
Printed edition: High density lipoproteins. Cham [Switzerland] : Springer Open, [2015] 9783319096643 (DLC) 2014958300 (OCoLC)900721901 |
| ISBN |
9783319096650 (electronic book) |
|
3319096656 (electronic book) |
|
9783319096643 (hardback ; alkaline paper) |
|
3319096648 (hardback ; alkaline paper) |
| Standard No. |
10.1007/978-3-319-09665-0 doi |
|
