Skip to content
You are not logged in |Login  
Limit search to available items
Book Cover
Author Wapner, Jessica.

Title The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level / Jessica Wapner ; foreword by Robert A. Weinberg.

Publication Info. New York, NY : The Experiment, LLC : Distributed by Workman Pub. Co., 2013.


Location Call No. Status
 Enfield, Main Library - Adult Department  616.99 WAP    Check Shelf
 Newington, Lucy Robbins Welles Library - Adult Department  616.99 WAPNER    In Transit +1 HOLD
 Portland Public Library - Adult Department  616.99 WAP    Check Shelf
 Southington Library - Adult  616.99 WAP    Check Shelf
Description xiii, 303 pages, 8 unnumbered pages of plates : illustrations (some color) ; 24 cm
Note "This book draws extensively from interviews [the author] conducted with those who lived this story. Chronic myeloid leukemia (CML), the blood cancer that is this book's focus, is alternately referred to as chronic myelogenous leukemia."--Author's note.
Bibliography Includes bibliographical references (pages 283-290) and index.
Contents Down to the bone : February 2012 -- The chromosome and the disease : 1959-1990. The first clue ; Three hundred words ; Investigating a chicken virus ; Right number, wrong place ; The surprising source of the chicken cancer gene ; Consummate instigators ; Where the kinase hangs the keys ; A chemical amputation ; Stripping away the fur and the fat ; A funny new protein ; The first sign of a human cancer gene ; Spelling out the translocation ; "That word is oncogenes" -- Rational design : 1983-1998. Becoming a doctor, and then a scientist ; Turning a protein into a drug target ; A machine with a virus for a motor ; Plucking the low-hanging fruit ; A drug in search of a disease; Two endings ; Getting out of Boston ; Killing cells ; Gain and loss ; "Not over my dead body will this compound go into man" -- Human trials : 1998-2001. The quickest answer ; Getting to 200 milligrams ; The one thing they didn't have ; Buzz in the chat rooms ; Saving their own lives ; A response rate of one hundred percent ; Good stressful ; Putting it in writing ; A truckload of data ; The fathers of victory -- Aftermath. A price to pay ; Showing a weakness ; The first five years ; The second generation ; A Gleevec for every cancer -- Survival time.
Summary This work focuses on what is widely viewed as the 'poster child' of rational drug development in the cancer research world. The history of the founding of a genetic mutant chromosome in the indication of Chronic myeloid leukemia disease, and the subsequent development of "Gleevec," is the keynote of this astounding publication.
Subject Chronic myeloid leukemia -- History.
Chronic myeloid leukemia -- Genetic aspects.
Cancer -- Genetic aspects.
Cancer -- Research.
Mutation (Biology)
Hungerford, David S., 1938-
Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- history -- United States.
Philadelphia Chromosome -- United States.
Fusion Proteins, bcr-abl -- history -- United States.
Genetic Therapy -- history -- United States.
Added Author Weinberg, Robert A. (Robert Allan), 1942-
ISBN 9781615190676 paperback $25.95
1615190678 paperback
9781615191659 (ebk.)
1615191658 (ebk.)
Add a Review