LEADER 00000cam  2200625 i 4500 
001    ocn900869876 
003    OCoLC 
005    20170308100626.0 
008    150123t20152015mdua     b    001 0 eng   
010      2015002906 
016 7  101650220|2DNLM 
019    933725707 
020    9781421418018|q(hardcover ;|qacic-free paper) 
020    1421418010|q(hardcover ;|qacid-free paper) 
020    |z9781421418025|q(electronic) 
020    |z1421418029|q(electronic) 
035    (OCoLC)900869876|z(OCoLC)933725707 
040    DNLM/DLC|beng|erda|cDLC|dYDX|dNLM|dBTCTA|dYDXCP|dBDX|dCUI
       |dOCLCF|dVET|dVP@|dDAC|dMNY|dWEA|dOCLCQ|dSTJ 
042    pcc 
049    STJJ 
050 00 RC582|b.P38 2015 
060 00 2015 J-892 
060 10 QW 540 
082 00 616.07/9|223 
092    616.079|bP324I 
100 1  Paul, William E.,|eauthor. 
245 10 Immunity /|cWilliam E. Paul, MD. 
264  1 Baltimore :|bJohns Hopkins University Press,|c[2015] 
300    xiii, 260 pages :|billustrations ;|c24 cm 
336    text|btxt|2rdacontent 
337    unmediated|bn|2rdamedia 
338    volume|bnc|2rdacarrier 
504    Includes bibliographical references and index. 
505 00 |gPart 1.|tImmunology.|tDefense and danger ;|tTracing an 
       immune response ;|tThe laws of immunology: universality, 
       tolerance, and appropriateness ;|tGrowing up and learning 
       immunology --|gPart 2.|tThe first law: universality.
       |tVaccines and serum therapy ;|tHow is specificity 
       achieved? ;|tImmunology's "eureka": clonal selection ;
       |tHow does each lymphocyte develop a distinct receptor? ;
       |tB cells and T cells recognize different types of 
       antigens ;|tMy foray into the specificity problem ;|tGenes
       and immune response ;|tThe Laboratory of Immunology and 
       the T-cell receptor --|gPart 3.|tThe second law: 
       tolerance. ;|tWhat is tolerance? ;|tHow does tolerance 
       develop? ;|tRegulatory T cells and the prevention of 
       autoimmunity --|gPart 4.|tThe third law: appropriateness.
       |tDifferent structures, different functions ;|tSpecific 
       types of infections, specific types of T-cell responses ;
       |tOur discovery of IL-4 and the cells that make it ;|tCD8 
       T cells: killer cells and friends ;|tDendritic cells: the 
       cells that interpret the infectious threat --|gPart 5.
       |tHow did the immune system evolve?.|tAn "ancient" immune 
       response controls "modern" immunity ;|tThe microbiome and 
       innate immunity ;|tEvolution of the immune system and 
       innate lymphoid cells --|gPart 6.|tAIDS, autoimmunity, 
       allergy, cancer, and transplantation.|tThe HIV epidemic 
       and the Office of AIDS Research ;|tHow the immune system 
       causes rheumatoid arthritis and lupus ;|tAllergy and 
       asthma ;|tInterleukin-4 and allergy ;|tCan the immune 
       system control cancer? ;|tNew parts for old: bone marrow 
       and organ transplantation ;|tJulien --|gConclusion.|tThe 
       future of immunology. 
520    "The immune system has incredible power to protect us from
       the ravages of infection. Boosted by vaccines, it can 
       protect us individually and as a "herd" from diseases such
       as measles. However, the power of the immune system is a 
       double-edged sword: an overactive immune system can wreak 
       havoc, destroying normal tissue and causing diseases such 
       as type I diabetes, rheumatoid arthritis, and multiple 
       sclerosis. The consequences of an impaired immune system, 
       on the other hand, are all too evident in the clinical 
       agonies of AIDS. Packed with illustrations, stories from 
       Dr. William E. Paul's distinguished career, and 
       fascinating accounts of scientific discovery, Immunity 
       presents the three laws of the human immune system--
       universality, tolerance, and appropriateness--and explains
       how the system protects and harms us. From the tale of how
       smallpox was overcome and the lessons of the Ebola 
       epidemic to the hope that the immune system can be used to
       treat or prevent cancer, Dr. Paul argues that we must take
       advantage of cutting-edge technologies and promising new 
       tools in immunological research."--Jacket. 
650  0 Immunity. 
650  0 Immune system. 
650  0 Immunologic diseases. 
650  7 Immune system.|2fast|0(OCoLC)fst00967877 
650  7 Immunity.|2fast|0(OCoLC)fst00967888 
650  7 Immunologic diseases.|2fast|0(OCoLC)fst00967977 
650 12 Immune System Phenomena. 
650 12 Immunity. 
650 22 Immune System Diseases|ximmunology. 
994    C0|bSTJ