LEADER 00000cam  2200649Ki 4500 
001    ocn823505341 
003    OCoLC 
005    20160518075638.4 
006    m     o  d         
007    cr cnu---unuuu 
008    130107s2004    njua    ob    001 0 eng d 
019    666953931|a815743884|a849916858|a922951937 
020    9789812567222|q(electronic bk.) 
020    9812567224|q(electronic bk.) 
035    (OCoLC)823505341|z(OCoLC)666953931|z(OCoLC)815743884
       |z(OCoLC)849916858|z(OCoLC)922951937 
040    N$T|beng|epn|erda|cN$T|dIDEBK|dI9W|dOCLCF|dNLGGC|dOCL
       |dYDXCP|dE7B|dEBLCP|dOCLCQ 
049    GTKE 
050  4 QL537.D76|bM48 2004eb 
060  4 QX 505|bM592 2004 
082 04 595.77/4|222 
084    42.64|2bcl 
245 00 Methuselah flies :|ba case study in the evolution of aging
       /|c[edited by] Michael R. Rose, Hardip B. Passananti, 
       Margarida Matos. 
264  1 River Edge, N.J. :|bWorld Scientific,|c[2004] 
264  4 |c©2004 
300    1 online resource (xiv, 479 pages) :|billustrations 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
504    Includes bibliographical references and indexes. 
505 0  Creation and long-term evolution of Methuselah flies -- 
       Stress, resistance, physiology, and aging -- Reproduction,
       nutrition, and aging -- Genetics and molecular biology of 
       Methuselah flies -- Reverse evolution of Methuselah flies 
       -- Aging, development, and crowding. 
520    Methuselah Flies presents a trailblazing project on the 
       biology of aging. It describes research on the first 
       organisms to have their lifespan increased, and their 
       aging slowed, by hereditary manipulation. These organisms 
       are fruit flies from the species Drosophila melanogaster, 
       the great workhorse of genetics. Michael Rose and his 
       colleagues have been able to double the lifespan of these 
       insects, and improved their health in numerous respects as
       well. The study of these flies with postponed aging is one
       of the best means we have of understanding, and ultimately
       achieving, the postponement of aging in humans. As such, 
       the carefully presented detail of this book will be of 
       value to research devoted to the understanding and control
       of aging. Methuselah Flies: is a tightly edited 
       distillation of twenty years of work by many scientists; 
       contains the original publications regarding the longer-
       lived fruit flies; offers commentaries on each of the 
       topics covered - new, short essays that put the individual
       research papers in a wider context; gives full access to 
       the original data; captures the scientific significance of
       postponed aging for a wide academic audience. 
588 0  Print version record. 
650  0 Drosophila melanogaster. 
650  0 Aging|xGenetic aspects. 
650  0 Evolution. 
650  0 Drosophila|xAging. 
650  0 Insects|xAging. 
650  2 Drosophila|xgenetics. 
650  2 Aging|xgenetics. 
650  2 Aging|xphysiology. 
650  2 Directed Molecular Evolution|xmethods. 
650  7 NATURE|xAnimals|xInsects & Spiders.|2bisacsh 
650  7 SCIENCE|xLife Sciences|xZoology|xEntomology.|2bisacsh 
650  7 Aging|xGenetic aspects.|2fast|0(OCoLC)fst00800307 
650  7 Drosophila melanogaster.|2fast|0(OCoLC)fst00898408 
650  7 Evolution.|2fast|0(OCoLC)fst00917265 
650  7 Drosophila.|2gtt 
650  7 Veroudering (biologie, psychologie)|2gtt 
650  7 Genetica.|2gtt 
700 1  Rose, Michael R.|q(Michael Robertson),|d1955- 
700 1  Passananti, Hardip Brar. 
700 1  Matos, Margarida. 
776 08 |iPrint version:|tMethuselah flies.|dRiver Edge, N.J. : 
       World Scientific, ©2004|z9812387412|w(DLC)  2007273646
       |w(OCoLC)57351600 
914    ocn823505341 
994    93|bGTK