Global trends in oral cancer epidemiology in the XXth century -- Insulin resistance, hyperinsulinemia, and cancer risk -- Hyperglycemia, type-2 diabetes, and cancer risk -- The role of estrogen in health and disease -- Estrogen deficiency as cancer risk factor -- Re-evaluation of the epidemiological associations of female sexual steroids and cancer risk -- Insulin resistance, estrogen deficiency and cancer risk -- Hormonal and metabolic risk factors for oral cancer among non-smoker, non-drinker women.