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Title Behçet's disease : from genetics to therapies / Yoshiaki Ishigatsubo, editor.

Publication Info. Tokyo : Springer, 2015.

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 University of Saint Joseph: Pope Pius XII Library - Internet  WORLD WIDE WEB E-BOOK SPRINGER    Downloadable
University of Saint Joseph patrons, please click here to access this SpringerLink resource
Description 1 online resource (ix, 176 pages) : illustrations (some color)
text file PDF rda
Note Includes index.
Online resource; title from PDF title page (SpringerLink, viewed February 19, 2015).
Contents 1. Overview -- 2. The Immunopathology of Behçet's Disease -- 3. Genetics -- 4. Ocular Involvement -- 5. Vascular Involvement of Behçet's Disease -- 6. Neurological Involvement -- 7. Gastrointestinal Involvement -- 8. Mucocutaneous Manifestations -- 9. Perspective.
Summary This book, besides reviewing basic and clinical aspects of Behçet's disease, covers the latest findings, including genetic studies and treatment with biologics for the disease. Although the cause of Behçet's disease is still unknown, it is well known that genetic factors, such as HLA-B51, are involved in its development. Recently, novel susceptibility loci including IL10, IL23R-IL12RB2, and endoplasmic reticulum aminopeptidase 1 have been identified, providing new insights into the pathogenesis of the disease. In addition to basic research, the beneficial efficacy of anti-TNF-alpha monoclonal antibodies has also been suggested for not only uveitis associated with the disease but also other subtypes of the disease such as entero-, vasculo-, and neuro- Behçet's disease. Behçet's Disease: From Genetics to Therapies provides essential information both for basic researchers working in the fields of immunology, inflammation, and genetics, and for clinical physicians who are interested in Behçet's disease, such as ophthalmologists, rheumatologists, dermatologists, gastroenterologists, neurologists, and vascular surgeons.
Bibliography Includes bibliographical references and index.
Subject Behçet's disease -- Genetic aspects.
Behçet's disease -- Diagnosis.
Behçet's disease -- Treatment.
Behcet Syndrome.
Medicine & Public Health.
Allergology.
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Added Author Ishigatsubo, Yoshiaki, editor.
Other Form: Printed edition: 9784431544869
Standard No. 10.1007/978-4-431-54487-6 doi
ISBN 9784431544876 (electronic bk.)
4431544879 (electronic bk.)
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