LEADER 00000cz a2200241n 4500 001 D007166 003 DNLM 005 20230901000000.0 008 990101 n ancnnbabn || ana 010 D007166 024 8 |0https://id.nlm.nih.gov/mesh/D007166 040 DNLM|cDNLM|dMvI 060 0 QW 955 072 D27.|x505.|x696.|x477.|x656 150 Immunosuppressive Agents 450 |wnnna|aImmunosuppressants 450 Immunosuppressant 450 Immunosuppressive Agent 450 |wnnna|aAgent, Immunosuppressive 450 |wnnna|aAgents, Immunosuppressive 550 Antirheumatic Agents 680 |iAgents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. 688 66(64)