LEADER 00000cam  2200565Li 4500 
001    ocm45730089  
003    OCoLC 
005    20160518075555.1 
006    m     o  d         
007    cr cn||||||||| 
008    001009s1995    inu     ob    001 0 eng d 
020    0585257604|q(electronic bk.) 
020    9780585257600|q(electronic bk.) 
035    (OCoLC)45730089 
040    N$T|beng|epn|erda|cN$T|dOCL|dOCLCQ|dYDXCP|dOCLCQ|dTUU
       |dOCLCQ|dTNF|dOCLCQ|dNHA|dNLGGC|dOCLCQ 
049    GTKE 
050  4 RA644.A25|bG73 1995eb 
082 04 174/.2|220 
100 1  Grady, Christine. 
245 14 The search for an AIDS vaccine :|bethical issues in the 
       development and testing of a preventive HIV vaccine /
       |cChristine Grady. 
264  1 Bloomington, Ind. :|bIndiana University Press,|c[1995] 
264  4 |c©1995 
300    1 online resource (193 pages). 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
490 1  Medical ethics series 
504    Includes bibliographical references (pages 163-185) and 
       index. 
505 0  Vaccines and their development: historical, social, and 
       scientific perspectives -- Human-subjects research and the
       regulation of drugs and biologicals -- Human-subjects 
       research and HIV vaccines -- The state of HIV vaccine 
       science -- Planning phase III HIV vaccine efficacy trials 
       -- Summary. 
520    Efforts to halt the spread of AIDS have failed so far, and
       the creation of a vaccine seems the best hope for 
       controlling the disease. Yet the process of developing and
       testing an HIV vaccine raises a host of difficult ethical 
       issues. Describing the role of vaccines in controlling 
       infectious disease, this study surveys the guidelines, 
       regulations, and attitudes concerning human-subjects 
       research. There is current information on the state of HIV
       research and the challenges facing scientists. Vaccine 
       research differs considerably from drug research, and 
       Grady explores the current wisdom governing research with 
       human subjects. Proposing a model for the ethical conduct 
       of vaccine research in general, this book applies it to 
       the complex case of an HIV vaccine. Clinical trials are 
       already ongoing, and the next step, field trials to 
       determine efficacy, involves another set of issues - and a
       call for new strategies for ethical conduct. The Search 
       for an AIDS Vaccine is essential reading for everyone 
       interested in ethics and the conduct of HIV vaccine 
       research. 
588 0  Print version record. 
650  0 AIDS (Disease)|xVaccination|xMoral and ethical aspects. 
650  0 AIDS (Disease)|xPrevention|xMoral and ethical aspects. 
650  0 AIDS (Disease)|xResearch|xMoral and ethical aspects. 
650  0 Clinical trials|xMoral and ethical aspects. 
650  2 AIDS Vaccines. 
650  2 HIV Infections|xprevention & control. 
650  2 Clinical Trials as Topic. 
650  2 Ethics, Medical. 
650  2 Research. 
650  7 MEDICAL|xEthics.|2bisacsh 
650 17 AIDS.|2gtt 
650 17 Vaccins.|2gtt 
650 17 Medische ethiek.|2gtt 
776 08 |iPrint version:|aGrady, Christine.|tSearch for an AIDS 
       vaccine.|dBloomington, Ind. : Indiana University Press, 
       ©1995|z0253326192|w(DLC)   94035650|w(OCoLC)31242881 
830  0 Medical ethics series. 
914    ocm45730089 
994    93|bGTK