| Edition |
First edition |
| Description |
xxiii, 421 pages : illustrations (chiefly color), maps ; 28 cm |
| Bibliography |
Includes bibliographical references (pages 373-378) and index. |
| Contents |
About the authors -- Foreword -- Preface -- Acknowledgments -- Part 1: -- Introduction And Core Concepts: -- Chapter 1: Framing the field: -- Rationale for studying genetics and genomics -- Why study human genetics and genomics now? -- Divergent public reactions to the field -- Anticipated returns on educational investment -- Review questions and exercises -- Chapter 2: Introducing the core concepts: -- Chapter 3: Genetic variability -- Chapter 4: Growth, development, and reproduction -- Chapter 5: Transmission of genes -- Chapter 6: Structure of genes, chromosomes, and genomes -- Chapter 7: Expression of genes and genomes -- Chapter 8: Mutation -- Chapter 9: Biological evolution -- Chapter 10: Human individuality -- Chapter 11: Chromosome abnormalities -- Chapter 12: Single-gene defects -- Chapter 13: Multifactorial traits -- Chapter 14: Disorders of variable genomic architecture -- Chapter 15: Birth defects -- Chapter 16: Genetics of cancer -- Chapter 17: Detection and treatment of genetic disorders -- Chapter 18: Population and evolutionary genetics -- Chapter 19: Personalized genetics and genomics -- Chapter 3: Genetics: -- Heredity and variation -- History -- Conservation of genetic information -- Human variation -- Review questions and exercises -- Chapter 4: Growth, development, and reproduction: -- Chromosomes: number and nature -- Cell division -- Prenatal development -- Review questions and exercises -- Chapter 5: Transmission of genes: -- Familial similarities -- Mendellan inheritance -- Applying principles of gene segregation to genetic counseling -- Exceptions to expected Mendellan patterns -- Mitochondrial inheritance -- Review questions and exercises -- Chapter 6: Structure of genes, chromosomes, and genomes: -- Gene composition -- From genes and chromosomes to genomes -- Review questions and exercises -- Chapter 7: Expression of genes and genomes: -- Gene expression: history of research -- Ribonucleic Acids (RNAs) -- Transcription and processing -- Genetic code -- Translation: synthesis of an mRNA-directed polypeptide -- Regulation of gene expression -- Genomic variation -- Review questions and exercises -- Chapter 8: Mutation: -- Nature of mutations -- Review questions and exercises. |
|
Chapter 9: Biological evolution: -- Historical evidence supporting the theory of biological evolution -- Evolutionary principles -- Molecular evolution -- Review questions and exercises -- Chapter 10: Human individuality: -- Uniqueness -- Early observations regarding uniqueness -- Lessons from genomics -- Review questions and exercises -- Part 2: Genetic Disorders: -- Chapter 11: Chromosome abnormalities: -- Introduction to cytogenetics -- Clinical indications for chromosome analysis -- Impact of chromosome abnormalities on health -- Types of chromosome abnormalities -- Illustrative examples -- Review questions and exercises -- Chapter 12: Single-gene defects: -- Archibald Garrod -- Terms and principles -- Panorama of single-gene defects -- Illustrative examples -- Review questions and exercises -- Chapter 13: Multifactorial traits: -- Definitions and formulations -- Determining the role of genes -- Identification of specific susceptibility alleles -- Illustrative examples -- Review questions and exercises -- Chapter 14: Disorders of variable genomic architecture: -- Architecture of the genome -- Human genomic variation -- Illustrative examples -- Review questions and exercises -- Chapter 15: Birth defects: -- Introduction -- Embryonic development -- Developmental genetics -- Teratogens -- Illustrative examples -- Review questions and exercises -- Chapter 16: Genetics of cancer: -- Overview -- Biology of cancer -- Cancer genetics -- Cancer genes -- Genomic approaches to cancer -- Environment and cancer -- Illustrative examples -- Review questions and exercises -- Chapter 17: Detection and treatment of genetic disorders: -- Detection -- Genetic counseling -- Treatment -- Gene therapy -- Stem cell therapy -- Review questions and exercises -- Part 3: Populations And Individuals: -- Chapter 18: Population and evolutionary genetics: -- Terminology -- Hardy-Weinberg Law -- Factors that perturb Hardy-Weinberg equilibrium -- Ancestry and disease in the genomic era -- Evolution in populations -- Societal debates about evolution: science versus religion -- Review questions and exercises -- Chapter 19: Personalized genetics and genomics: -- DNA fingerprinting -- Genetics and medicines -- Pharmacogenetics -- Pharmacogenomics -- Direct-to-consumer genomic tests -- Review questions and exercises -- Glossary -- Additional reading -- Answers to review questions -- Credits and permissions -- Index. |
| Summary |
"In the nearly 60 years since Watson and Crick proposed the double helical structure of DNA, the molecule of heredity, waves of discoveries have made genetics the most thrilling field in the sciences. The study of genes and genomics today explores all aspects of the life with relevance in the lab, in the doctor's office, in the courtroom and even in social relationships. In this helpful guidebook, one of the most respected and accomplished human geneticists of our time communicates the importance of genes and genomics studies in all aspects of life. With the use of core concepts and the integration of extensive references, this book provides students and professionals alike with the most in-depth view of the current state of the science and its relevance across disciplines."--Publisher's website. |
| Subject |
Human genetics.
|
|
Medical genetics.
|
|
Genomics.
|
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Genetic Phenomena.
|
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Genetic Diseases, Inborn.
|
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Genomics.
|
|
Genomics. (OCoLC)fst00940228
|
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Human genetics. (OCoLC)fst00963075
|
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Medical genetics. (OCoLC)fst01014133
|
| Added Author |
Rosenberg, Diane Drobnis, 1944-
|
| ISBN |
9780123852120 |
|
0123852129 |
|
