Where do we come from? What are we? Where are we going? -- The standard model of particle physics -- Why physics is the easiest science-- effective theories -- Supersymmetry and sparticles -- Testing supersymmetry experimentally -- What is the universe made of? -- Higgs physics -- Some additional help from supersymmetry, and some challenges -- Supersymmetry, string theory, and the primary theory -- Can we really understand the origin of the universe and its natural law(s)?