| Description |
1 online resource |
| Bibliography |
Includes bibliographical references and index. |
| Note |
Online resource; title from PDF title page (ScienceDirect, viewed March 19, 2019). |
| Contents |
Front Cover; Reproducibility in Biomedical Research; Copyright Page; Dedication; Quote; Contents; Preface; Prologue; 1 Introduction; Science as Argumentation Within the Experiment and Within the Community; Scientific Argumentation and Logic; The Multifaceted Notion of Irreproducibility; Productive Irreproducibility; Ontology Versus Epistemology; The Use of Logical Formalism; Summary; 2 The Problem of Irreproducibility; Type I and II Errors; Controlling the Inevitability of Irreproducibility Risk; Institutional Responses; Reproducibility and Irreproducibility |
|
Contributions of Logic to Biomedical ResearchReductionism and Conceptual (Broad) Irreproducibility; Variability, Central Tendency, Chaos, and Complexity; Conceptual Reproducibility and the Importance of Hypothesis Generation; Summary; 3 Validity of Biomedical Science, Reproducibility, and Irreproducibility; Science Must Be Doing Something Right and Therein Lies Reproducibility and Productive Irreproducibility; Science Versus Human Knowledge of It; The Necessity of Enabling Assumptions; The Centrality of Reproducibility; The Central Tendency; The Scientific Method; Reductionism; Causality |
|
Special Cases of Irreproducible ReproducibilityScience as Inference to the Best Explanation; Summary; 4 The Logic of Certainty Versus the Logic of Discovery; Certainty, Reproducibility, and Logic; Deductive Logic-Certainty and Limitations; Syllogistic Deduction; Judicious Use of the Fallacy of Four Terms; Partial, Probability, Practical, and Causal Syllogisms; Propositional Logic; Induction; The Duhem-Quine Thesis; Summary; 5 The Logic of Probability and Statistics; The Value of the Logical Perspective in Probability and Statistics |
|
Metaphysics: Ontology Versus Epistemology and Biomedical ReproducibilityIndependence of Probabilities and Regression Toward the Mean; Avoiding the Fallacy of Four Terms; The Conflation of Ontology and Epistemology; Summary; 6 Causation, Process Metaphor, and Reductionism; Practical Syllogism and Beyond; Centrality of Hypothesis to Experimentation and Centrality of Causation to Hypothesis Generation; Reductionism and the Fallacies of Composition and Division; Other Fallacies as Applied to Cause; Discipline in the Principle of Causational and Informational Synonymy; Summary |
|
7 Case Studies in Clinical Biomedical ResearchForbearance of Repetition; Setting the Stage; Clinical Meaningfulness; Statistics and Internal Validity; Establishing Clinical Meaningfulness; Specific Features to Look for in Case Studies; Case Study-Two Conflicting Studies of Hormone Use in Postmenopausal Women, Which Is Irreproducible?; Summary; 8 Case Studies in Basic Biomedical Research; Forbearance of Repetition; Purpose; Setting the Stage; The Value of a Tool from Its Intended Use; What is Basic Biomedical Research?; Scientific Meaning Versus Statistical Significance |
| Subject |
Biology -- Research.
|
|
Medicine -- Research.
|
|
Reproducible research.
|
|
NATURE -- Reference.
|
|
SCIENCE -- Life Sciences -- Biology.
|
|
SCIENCE -- Life Sciences -- General.
|
|
Biology -- Research. (OCoLC)fst00832448
|
|
Medicine -- Research. (OCoLC)fst01015059
|
|
Reproducible research. (OCoLC)fst01904473
|
| Other Form: |
Print version: Montgomery, Erwin B., Jr. Reproducibility in biomedical research. London, United Kingdom : Academic Press, an imprint of Elsevier, 2019 0128174439 9780128174432 (OCoLC)1048933746 |
| ISBN |
9780128176726 (electronic book) |
|
0128176725 (electronic book) |
|
9780128174432 (print) |
|
0128174439 |
|
