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020    331960192X|q(electronic book) 
020    |z9783319601915|q(print) 
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024 7  10.1007/978-3-319-60192-2|2doi 
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037    com.springer.onix.9783319601922|bSpringer Nature 
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082 04 572.8|223 
245 00 Genome editing in neurosciences /|cRudolf Jaenisch, Feng 
       Zhang, Fred Gage, editors. 
264  1 Cham, Switzerland :|bSpringer,|c2017. 
300    1 online resource (xi, 123 pages) :|bcolor illustrations. 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
347    text file|bPDF|2rda 
490 1  Research and perspectives in neurosciences,|x0945-6082 
505 0  Introduction -- In vitro modeling of complex neurological 
       diseases -- Aquatic model organisms in neurosciences : the
       genome editing revolution -- Genome-wide genetic screening
       in the mammalian CNS -- CRISPR/Cas9-mediated Knockin and 
       Knockout in Zebrafish -- Dissecting the role of synaptic 
       proteins with CRISPR -- Recurrently Breaking Genes in 
       Neural Progenitors: Potential Roles of DNA Breaks in 
       Neuronal Function, Degeneration and Cancer -- Neuroscience
       research using non-human primate models and genome editing
       -- Multiscale genome engineering: Genome-wide screens and 
       targeted approaches -- Using Genome Engineering to 
       Understand Huntington's Disease -- Therapeutic gene 
       editing in muscles and muscle stem cells. 
506 0  Open access.|5GW5XE 
520    This book is open access under a CC BY 4.0 license. 
       Innovations in molecular biology are allowing 
       neuroscientists to study the brain with unprecedented 
       resolution, from the level of single molecules to 
       integrated gene circuits. Chief among these innovations is
       the CRISPR-Cas genome editing technology, which has the 
       precision and scalability to tackle the complexity of the 
       brain. This Colloque Médecine et Recherche has brought 
       together experts from around the world that are applying 
       genome editing to address important challenges in 
       neuroscience, including basic biology in model organisms 
       that has the power to reveal systems-level insight into 
       how the nervous system develops and functions as well as 
       research focused on understanding and treating human 
       neurological disorders. 
588 0  Online resource; title from PDF title page (SpringerLink, 
       viewed September 25, 2017). 
590    SpringerLink|bSpringer Nature Open Access eBooks 
650  0 Neurogenetics. 
650  0 Genetic engineering. 
650  0 RNA editing. 
650  2 Gene Editing. 
650  7 Neurosciences.|2bicssc 
650  7 Genetic engineering.|2fast|0(OCoLC)fst00940027 
650  7 Neurogenetics.|2fast|0(OCoLC)fst01036353 
650  7 RNA editing.|2fast|0(OCoLC)fst01086255 
700 1  Jaenisch, Rudolf,|eeditor. 
700 1  Zhang, Feng,|d1982-|eeditor. 
700 1  Gage, F.|q(Fred),|d1950-|eeditor. 
776 08 |iPrint version:|tGenome editing in neurosciences.|dCham, 
       Switzerland : Springer, 2017|z9783319601915|z3319601911
       |w(OCoLC)987282339 
830  0 Research and perspectives in neurosciences.|x0945-6082 
914    on1004664421 
994    92|bSTJ