| Description |
1 online resource |
| Bibliography |
Includes bibliographical references and index. |
| Summary |
The 'RNA world' hypothesis that proposed RNA molecules as the first form of genetic material was put forwarded in the late 1980s but got impetus only recently when high-throughput sequencing technologies began unearthing new types of non-coding RNA (ncRNA) transcripts in higher eukaryotes. Till then, research on ncRNAs were primarily confined to transfer RNAs and, ribosomal RNAs, which act as the messengers of the protein synthesis and allow translation of genetic information encoded by DNA into proteins. In recent years, the integration of high-throughput genomic technologies with molecular biology and omics sciences have revolutionized the fields of ncRNA research by identifying the hidden treasures of several new types of ncRNAs encoded in the genomes of several organisms and decrypting their versatile roles in gene expression and epigenetics. Among these, two small endogenous ncRNAs, namely microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs) that drive argonaute (AGO) family of proteins namely Ago and Piwi respectively and silence the expression of genes have geared up molecular and disease biology research in recent years. Both miRNAs and piRNAs are expressed in higher eukaryotes, including human and act as cellular rheostats by regulating the expression of significant fraction of genes encoded in the genomes. The aberrant expressions of these small ncRNAs within the cells cause various abnormalities and diseases including cancer. Manipulating their aberrant expression or function can serve as potential novel diagnostic/prognostic biomarkers and bring in new therapeutic strategies for multiple human diseases. This can be further translated from bench-side to clinic for improving human health. This book captures the essence of the pioneering work of some of the world's leading researchers showcasing the scientific excitements surrounding the evolving regulatory roles of miRNAs and piRNAs highlighting their potential towards the diagnosis and therapeutics of various diseases. The book is geared towards scientists, students, and will particularly appeal to active investigators in RNA biology, molecular biology, cancer research as well as clinicians and will provide them a comprehensive view of recent discoveries and research progresses to utilize miRNAs, piRNAs and their interacting proteins, Ago and Piwi for diagnosis, prognosis and therapeutics of diseases. Provides a unified cutting-edge resource for both miRNAs and piRNAs, two promising AGO-clade small ncRNAs, their functions and potential applicationsShowcase high-throughput technologies and other approaches for discovery of these small ncRNAs and their targetsUnveils the diverse molecular mechanisms by which miRNAs and piRNAs regulate gene expression in animal cellsShowcase recent discoveries on involvement of Argonaute and Piwi proteins in different biological processes and diseases as well as their possible use in diagnosisReport breakthroughs in the use of small ncRNAs for diagnosis and personalized therapy |
| Contents |
Front Cover; AGO-Driven Non-Coding RNAs: Codes to Decode the Therapeutics of Diseases; Copyright; Contents; Contributors; About the Editor; Preface; About the Book; Part: 1 Small non-coding RNA biology and prediction methods; Chapter 1 Two different mechanisms of two different non-coding RNAs-MicroRNAs and PIWI-interacting RNAs: From origin to ca ... ; 1 History of MicroRNAs; 2 Biogenesis of MicroRNAs; 3 Functions of MicroRNAs; 3.1 Roles of MicroRNAs and Their Effects on Cancer; 3.1.1 Tumor suppressor microRNAs; 3.1.2 Oncogenic microRNAs (oncomiRs); 3.1.3 MetastamiRs |
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4 History of PIWI-Interacting RNAs5 Classification of piRNAs; 6 Biogenesis of piRNAs; 6.1 The Primary Pathway; 6.2 The Secondary/Amplification Loop (Ping-Pong) Pathway; 7 Functions of piRNAs and PIWI Proteins; 8 piRNAs/PIWI Proteins and Cancer; 9 Conclusion; References; Chapter 2 Computational methods for microRNA and PIWI-interacting RNA gene discovery and functional predictions; 1 Introduction; 2 Computational Methods for the Identification of MicroRNA Genes; 2.1 MicroRNA Biogenesis and Function; 2.2 Ab Initio MicroRNA Discovery |
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2.3 High-Throughput RNA Sequencing Analysis for MicroRNA Discovery2.4 Functional Validation of Predicted MicroRNA Genes; 3 Computational Identification of PIWI-Interacting RNAs; 4 Computational Methods to Predict MicroRNA's Functions; 4.1 In Silico Methods and Tools to Infer microRNAs' Function; 4.2 Predict MicroRNA-Disease Associations; 4.3 Network-Based Approaches for MicroRNA's Functional Prediction; 5 Exploration of PIWI-Interacting RNA's Functions Using In Silico Methods; 6 Conclusion; References; Part: 2 Small ncRNAs dictating cell fate and immune response |
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Chapter 3 The role of microRNAs in bacterial infections1 Introduction; 2 Mammalian Toll-Like Receptors and Bacterial Infection; 3 MicroRNAs Regulating the Inflammatory Response of Immune Cells to Infection; 4 Autophagy and Its Regulation During Bacterial Infection; 5 Concluding Remarks; Acknowledgments; References; Chapter 4 MicroRNAs shaping cellular reprogramming; 1 Introduction; 2 MicroRNAs and Cellular Reprogramming; 2.1 Importance of MicroRNA in Pluripotent Stem Cells; 2.1.1 miR-17~92 cluster; 2.1.2 miR-290 ~ 295 cluster; 2.1.3 miR-302 ~ 367 cluster |
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2.1.4 Let-7 microRNAs reverse the effect of pluripotency-promoting microRNAs2.2 MicroRNAs Serve as Key Players in Cellular Reprogramming; 2.3 Influence of Metabolic Signaling Pathways and Cell Culture Conditions on MicroRNA Expression and Function in Reprogra ... ; 3 Role of MicroRNAs in Reprogramming Associated Cellular Events; 3.1 Regulation of Cell Cycle; 3.2 Regulation of Mesenchymal to Epithelial Transition; 3.3 Regulation of DNA Methylation; 3.4 Regulation of Cell Apoptosis; 3.5 Regulation of the p53 Pathway; 4 Role of MicroRNAs in Trans-Differentiation |
| Note |
Online resource; title from digital title page (viewed on February 28, 2019). |
| Subject |
Non-coding RNA.
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RNA-protein interactions.
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SCIENCE -- Life Sciences -- Biochemistry.
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Non-coding RNA. (OCoLC)fst01741020
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RNA-protein interactions. (OCoLC)fst01086260
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| Added Author |
Mallick, Bibekanand, editor.
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| Other Form: |
Print version: 0128156694 9780128156698 (OCoLC)1047781416 |
| ISBN |
9780128156704 (electronic book) |
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0128156708 (electronic book) |
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9780128156698 (paperback) |
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0128156694 (paperback) |
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