| Description |
xii, 294 pages, 6 unnumbered pages of plates : illustrations (some color) ; 24 cm |
| Bibliography |
Includes bibliographical references and index. |
| Contents |
Computational approaches in peptide and protein design : an overview / Gregory Nikiforovich and Garland R. Marshall -- Aspects of peptidomimetics / Veronique Maes and Dirk Tourwé -- Design of cyclic peptides / Oliver Demmer, Andreas O. Frank, and Horst Kessler -- Carbohydrates in peptide and protein design / Knud J. Jensen and Jesper Brask -- De novo design of proteins / Knud J. Jensen -- Design of insulin variants for improved treatment of diabetes / Thomas Hoeg-Jensen. |
| Summary |
"Peptides serve as effective drugs in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this researchers are developing new methods to create 'tailor-made' peptides and proteins with improved pharmacological properties. Design of Peptides and Proteins provides an overview of the experimental and computational methods for peptide and protein design, with an emphasis on specific applications for therapeutics and biomedical research. Topics covered include: Computer modeling of peptides and proteins; Peptidomimetics design and synthesis of cyclic peptides; Carbohydrates in peptide and protein design; De novo design of peptides and proteins; Medical development applications; An extended case study - the design of insulin variants."--Google Books. |
| Subject |
Peptide drugs -- Design.
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Protein drugs -- Design.
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Peptides -- Design.
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Protein engineering.
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Peptides -- chemistry.
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Proteins -- chemistry.
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Drug Design.
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| Added Author |
Jensen, Knud J.
|
| ISBN |
9780470319611 |
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0470319615 |
|
9780470749715 |
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0470749717 |
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