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008    180410s2018    si a    o     000 0 eng d 
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024 7  10.1007/978-981-10-8488-1|2doi 
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037    com.springer.onix.9789811084881|bSpringer Nature 
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050  4 QP364.7 
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082 04 612.8/042|223 
245 00 Nicotinic acetylcholine receptor signaling in 
       neuroprotection /|cAkinori Akaike, Shun Shimohama, Yoshimi
       Misu, editors. 
264  1 Singapore :|bSpringer,|c2018. 
300    1 online resource (x, 191 pages) :|billustrations (some 
       color) 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
347    text file|bPDF|2rda 
505 0  1. Overview -- 2. In vivo imaging of nicotinic 
       acetylcholine receptors in the central nervous system -- 
       3.A new aspect of cholinergic transmission in the central 
       nervous system -- 4. Nicotinic acetylcholine receptor 
       signaling: roles in neuroprotection -- 5. Regulation by 
       nicotinic acetylcholine receptors of microglial glutamate 
       transporters: role of microglia in neuroprotection -- 6. 
       Shati/Nat8l and N-acetylaspartate (NAA) have important 
       roles in regulating nicotinic acetylcholine receptors in 
       neuronal and psychiatric diseases in animal models and 
       humans -- 7. Nicotinic acetylcholine receptors in 
       regulation of pathology of cerebrovascular disorders -- 8.
       Roles of nicotinic acetylcholine receptors in the 
       pathology and treatment of Alzheimer's and Parkinson's 
       diseases -- 9. SAK3-induced neuroprotection is mediated by
       nicotinic acetylcholine receptors -- 10. Removal of blood 
       amyloid as a therapeutic strategy for Alzheimer's disease:
       the influence of smoking and nicotine. 
506 0  Open access.|5GW5XE 
520    This open access book presents the roles and mechanisms of
       signal transduction triggered by nicotinic acetylcholine 
       receptors (nAChRs) stimulation in neuroprotection against 
       toxic effects of risk factors of neurodegenerative 
       diseases. Accumulating evidence suggests that nAChRs in 
       the CNS play important roles not only in excitatory 
       neurotransmission but also in neuronal survival and 
       related functions. Neuroprotection mediated by nAChRs in 
       neurodegenerative diseases such as Alzheimer's disease is 
       the major topic of this book. In response to rapidly 
       evolving areas in clinical and laboratory 
       neuropharmacology and neurochemistry, this volume provides
       in-depth coverage of neuroprotection in basic research and
       future developments in the clinical application of 
       effective neuroprotective strategies in neurodegenerative 
       diseases. This work appeals to both basic and clinical 
       researchers in several fields, such as neuroscience, 
       neurology, and pharmacology. This book is published with 
       open access under a CC BY 4.0 license. 
588 0  Online resource; title from PDF title page (SpringerLink, 
       viewed April 10, 2018). 
590    SpringerLink|bSpringer Nature Open Access eBooks 
650  0 Nicotinic receptors. 
650  0 Cellular signal transduction. 
650  0 Neuroprotective agents. 
650  7 Medical profession.|2bicssc 
650  7 Cellular signal transduction.|2fast|0(OCoLC)fst00850288 
650  7 Neuroprotective agents.|2fast|0(OCoLC)fst01743401 
650  7 Nicotinic receptors.|2fast|0(OCoLC)fst01037556 
700 1  Akaike, A.|q(Akinori),|d1951-|eeditor. 
700 1  Shimohama, Shun,|eeditor. 
700 1  Misu, Yoshimi,|d1934-|eeditor. 
776 08 |iPrint version:|tNicotinic acetylcholine receptor 
       signaling in neuroprotection.|dSingapore : Springer, 2018
       |z9811084874|z9789811084874|w(OCoLC)1020614170 
914    on1030963204 
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