LEADER 00000cam  2200000 a 4500 
001    ocn820450840 
003    OCoLC 
005    20130510024706.0 
008    121128s2013    nyuaf    b    001 0 eng   
010      2012047686 
016 7  101596695|2DNLM 
019    808772057 
020    9781615190676|qpaperback|c$25.95 
020    1615190678|qpaperback 
020    |z9781615191659 (ebk.) 
020    |z1615191658 (ebk.) 
035    (OCoLC)808772057 
035    (OCoLC)820450840|z(OCoLC)808772057 
035    (OCoLC)808772057 
040    DNLM/DLC|beng|cDLC|dIG#|dNLM|dBDX|dYDXCP|dBTCTA|dKLP|dOCO
       |dJAG|dOCLCO|dABG 
049    CKEA 
050  4 RC643|b.W36 2013 
060 10 QZ 11 AA1 
082 00 616.99/419042|223 
100 1  Wapner, Jessica. 
245 14 The Philadelphia chromosome :|ba mutant gene and the quest
       to cure cancer at the genetic level /|cJessica Wapner ; 
       foreword by Robert A. Weinberg. 
264  1 New York, NY :|bThe Experiment, LLC :|bDistributed by 
       Workman Pub. Co.,|c2013. 
300    xiii, 303 pages, 8 unnumbered pages of plates :
       |billustrations (some color) ;|c24 cm 
336    text|btxt|2rdacontent 
337    unmediated|bn|2rdamedia 
338    volume|bnc|2rdacarrier 
500    "This book draws extensively from interviews [the author] 
       conducted with those who lived this story. Chronic myeloid
       leukemia (CML), the blood cancer that is this book's focus,
       is alternately referred to as chronic myelogenous 
       leukemia."--Author's note. 
504    Includes bibliographical references (pages 283-290) and 
       index. 
505 0  Down to the bone : February 2012 -- The chromosome and the
       disease : 1959-1990. The first clue ; Three hundred words 
       ; Investigating a chicken virus ; Right number, wrong 
       place ; The surprising source of the chicken cancer gene ;
       Consummate instigators ; Where the kinase hangs the keys ;
       A chemical amputation ; Stripping away the fur and the fat
       ; A funny new protein ; The first sign of a human cancer 
       gene ; Spelling out the translocation ; "That word is 
       oncogenes" -- Rational design : 1983-1998. Becoming a 
       doctor, and then a scientist ; Turning a protein into a 
       drug target ; A machine with a virus for a motor ; 
       Plucking the low-hanging fruit ; A drug in search of a 
       disease; Two endings ; Getting out of Boston ; Killing 
       cells ; Gain and loss ; "Not over my dead body will this 
       compound go into man" -- Human trials : 1998-2001. The 
       quickest answer ; Getting to 200 milligrams ; The one 
       thing they didn't have ; Buzz in the chat rooms ; Saving 
       their own lives ; A response rate of one hundred percent ;
       Good stressful ; Putting it in writing ; A truckload of 
       data ; The fathers of victory -- Aftermath. A price to pay
       ; Showing a weakness ; The first five years ; The second 
       generation ; A Gleevec for every cancer -- Survival time. 
520    This work focuses on what is widely viewed as the 'poster 
       child' of rational drug development in the cancer research
       world. The history of the founding of a genetic mutant 
       chromosome in the indication of Chronic myeloid leukemia 
       disease, and the subsequent development of "Gleevec," is 
       the keynote of this astounding publication. 
600 10 Hungerford, David S.,|d1938- 
650  0 Chronic myeloid leukemia|xHistory. 
650  0 Chronic myeloid leukemia|xGenetic aspects. 
650  0 Cancer|xGenetic aspects. 
650  0 Cancer|xResearch. 
650  0 Mutation (Biology) 
650  0 Imatinib. 
650 12 Leukemia, Myelogenous, Chronic, BCR-ABL Positive|xhistory
       |zUnited States. 
650 12 Philadelphia Chromosome|zUnited States. 
650 22 Fusion Proteins, bcr-abl|xhistory|zUnited States. 
650 22 Genetic Therapy|xhistory|zUnited States. 
700 1  Weinberg, Robert A.|q(Robert Allan),|d1942- 
938    Ingram|bINGR|n9781615190676 
938    Brodart|bBROD|n103868143 
938    YBP Library Services|bYANK|n9618972 
938    Baker and Taylor|bBTCP|nBK0012006701 
994    92|bCKE