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Author Butler, John M. (John Marshall), 1969-

Title Forensic DNA typing : biology, technology, and genetics of STR markers / John M. Butler.

Publication Info. Burlington, MA : Elsevier Academic Press, [2005]


Location Call No. Status
 University of Saint Joseph: Pope Pius XII Library - Standard Shelving Location  572.86 B985F    Check Shelf
Edition Second edition.
Description xvii, 660 pages : illustrations (some color) ; 26 cm
Bibliography Includes bibliographical references and indexes.
Contents Overview and history of DNA typing -- DNA biology review -- Sample collection, DNA extraction and DNA quantitation -- The polymerase chain reaction (DNA amplification) -- Commonly used short tandem repeat markers and commercial kits -- Biology of STRs : stutter products, non-template addition, microvariants, null alleles, and mutation rates -- Forensic issues : degraded DNA, PCR inhibition, contamination, mixed samples and low copy number -- Single nucleotide polymorphisms and other bi-allelic markers -- Y chromosome DNA testing -- Mitochondrial DNA analysis -- Non-human DNA testing and microbial forensics -- DNA separation methods : slab-gel and capillary electrophoresis -- DNA detection methods : fluorescent dyes and silver-staining -- Instrumentation for STR typing : ABI 310, ABI 3100, FMBIO systems -- STR genotyping issues -- Laboratory validation -- New technologies, automation, and expert systems -- Combined DNA index system (CODIS) and the use of DNA databases -- Basic genetic principles, statistics, and probability -- STR population database analyses -- Profile frequency estimates, likelihood ratios, and source attribution -- Approaches to statistical analysis of mixtures and degraded DNA -- Kinship and parentage testing -- Mass disaster DNA victim identification.
Subject DNA fingerprinting.
Forensic genetics.
DNA -- Synthesis.
DNA Fingerprinting -- methods.
Databases, Nucleic Acid.
Forensic Medicine.
ISBN 0121479528 alkaline paper
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