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Title Murine models, energy balance, and cancer / Nathan A. Berger, editor.

Publication Info. Cham : Springer, [2015]


Location Call No. Status
 University of Saint Joseph: Pope Pius XII Library - Pharmacy Library  PHARM WORLD WIDE WEB E-BOOK SPRINGER    Downloadable
University of Saint Joseph patrons, please click here to access this SpringerLink resource
Description 1 online resource.
Series Energy balance and cancer, 2199-2630 ; 10
Energy balance and cancer ; v. 10. 2199-2630
Note Online resource; title from PDF title page (EBSCO, viewed June 25, 2015).
Bibliography Includes bibliographical references and index.
Contents Relevance of Circadian Rhythm in Cancer -- Environmental Manipulation and Neuropeptide Effects on Energy Balance and Cancer -- The MRL Mouse: A Model of Regeneration and Cancer -- Living Large: What Mouse Models Reveal about Growth Hormone and Obesity -- Mouse Models to Study Obesity Effects on Hematologic Malignancies -- Energy Balance, IGF-1 and Cancer: Causal Lessons from Genetically Engineered Mice -- Mouse Models to Study Leptin in Breast Cancer Stem Cells -- Mouse Models used to study the effects of Diabetes, Insulin and IGFs on cancer -- Impact of Energy Balance on Chemically Induced Mammary Carcinogenesis in the Rat -- Models and Mechanisms of High Fat Diet Promotion of Pancreatic Cancer -- Maternal energetics and the developmental origins of prostate cancer in offspring -- Mouse Models to Study the Effect of Natural Products on Obesity Associated -- Mouse Models to Study Metformin Effects in Carcinogenesis.
Summary This volume provides a transdisciplinary and translational review of many of the leading murine models used to study the mechanisms, mediators and biomarkers linking energy balance to cancer. It provides a review of murine models that should be of interest to basic, clinical and applied research investigators as well as nutrition scientists and students that work in cancer prevention, cancer control and treatment. The worldwide obesity pandemic has been extensively studied by epidemiologic and observational studies and even, in some cases, by randomized controlled trials. However, the development and control of obesity, its comorbidities and its impact on cancer usually occurs over such long periods that it is difficult, if not impossible to conduct randomized controlled trials in humans to investigate environmental contributions to obesity, energy balance and their impact on cancer. In contrast, model organisms, especially mice and rats, provide valuable assets for performing these studies under rigorously controlled conditions and in sufficient numbers to provide statistically significant results. In this volume, many of the leading and new murine models used to study the mechanisms and mediators linking cancer with obesity, sleep, exercise, their modification by environment and how they may continue to be used to further elucidate these relations as well as to explore preclinical aspects of prevention and/or therapeutic intervention are considered. This volume provides an important compilation and analysis of major experimental systems and principles for further preclinical research with translational impact on energy balance and cancer.
Subject Cancer -- Etiology -- Research.
Obesity -- Complications -- Research.
Bioenergetics -- Research.
Tumor markers -- Research.
Mice as laboratory animals.
HEALTH & FITNESS / Diseases / General.
MEDICAL / Clinical Medicine.
MEDICAL / Diseases.
MEDICAL / Evidence-Based Medicine.
MEDICAL / Internal Medicine.
Added Author Berger, Nathan A., editor.
Other Form: Printed edition: 9783319167329
Standard No. 10.1007/978-3-319-16733-6 doi
ISBN 9783319167336 (electronic bk.)
3319167332 (electronic bk.)
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