In 1480, Florentine investigator Guid' Antonio Vespucci and his nephew, Amerigo, are entangled in events that threaten to destroy them and their beloved city. Marauding Turks abduct a beautiful young Florentine girl and sell her into slavery. Then a holy painting in Guid' Antonio's family church begins to weep. Following a spellbinding trail of clues, Guid' Antonio pursues the truth about the missing girl and the painting's mystifying tears.