The redoubtable symbologist Robert Langdon finds proof that the Illuminati society is alive, well, and murderously active. Brilliant physicist Leonardo Vetra has been murdered, his eyes plucked out, and the society's ancient symbol branded upon his chest. His final discovery, antimatter, the most powerful and dangerous energy source known to man, has disappeared ; it is hidden beneath Vatican City on the eve of the election of a new pope. Langdon and Vittoria, Vetra's daughter and colleague, embark on a frantic hunt through the streets, churches, and catacombs of Rome, following a 400-year-old trail to the lair of the Illuminati, to prevent the incineration of civilization.