Includes bibliographical references (pages 193-265) and index.
Contents
The evolving concept of schizophrenia -- Candidate neuronal circuits -- When does schizophrenia begin? -- Clues from drugs that affect dopamine, glutamate, and other neurotransmitters -- Some clues from psychophysiology -- Neuropsychological studies -- Imaging brain structure in living patients -- Imaging brain function in living patients -- Imaging brain chemistry and the question of neuronal degeneration -- Pieces of the puzzle: likely components of the final common pathway -- Early models of the final common pathway: disconnection and coordination -- Early models of the final common pathway: basal ganglia-thalamocortical circuits -- Do the models fit with what we know about schizophrenia? -- Implications for treatment -- The way forward.