LEADER 00000cam  2200817Ii 4500 
001    on1076269058 
003    OCoLC 
005    20200516093951.0 
006    m     o  d         
007    cr cnu|||unuuu 
008    181126s2018    enk     o     000 0 eng d 
015    GBB8N1785|2bnb 
016 7  019144402|2Uk 
019    1076513020 
020    9780128095614|q(electronic book) 
020    012809561X|q(electronic book) 
020    |z9780128095560 
020    |z0128095563 
035    (OCoLC)1076269058|z(OCoLC)1076513020 
037    9780128095614|bIngram Content Group 
040    N$T|beng|erda|epn|cN$T|dN$T|dEBLCP|dOPELS|dUKMGB|dYDX
       |dOCLCF|dMERER|dOCLCQ|dESU|dCQ$|dOCLCQ|dSTJ 
049    STJJ 
050  4 R858.A3 
072  7 HEA|x012000|2bisacsh 
072  7 HEA|x020000|2bisacsh 
072  7 MED|x004000|2bisacsh 
072  7 MED|x101000|2bisacsh 
072  7 MED|x109000|2bisacsh 
072  7 MED|x029000|2bisacsh 
072  7 MED|x040000|2bisacsh 
072  7 MED|x092000|2bisacsh 
082 04 610.285|223 
099    WORLD|aWIDE|aWEB|aE-BOOK|aSCIENCE 
245 00 Leveraging Biomedical and Healthcare Data :|bSemantics, 
       Analytics and Knowledge /|cedited by Firas Kobeissy [and 3
       others]. 
250    First edition. 
264  1 London :|bElsevier Ltd. :|bAcademic Press,|c2018. 
300    1 online resource 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
505 0  Front Cover; Leveraging Biomedical and Healthcare Data: 
       Semantics, Analytics and Knowledge; Copyright; Dedication;
       Contents; Contributors; Foreword I; Foreword II; Preface; 
       Acknowledgments; Chapter 1: Comprehensive Workflow for 
       Integrative Transcriptomics Meta-Analysis; 1. 
       Introduction; 2. Data Preparation; 2.1. Data Download; 
       2.2. Quality Control; 2.2.1. Single-Array Metrics; 2.2.2. 
       Multiarray Metrics; 2.3. Data Preprocessing; 2.3.1. 
       Background Correction; 2.3.2. Normalization; 2.3.3. 
       Summarization; 2.3.4. Comparison Between Different 
       Procedures 
505 8  2.4. Batch Effect: A Special Concern During Data 
       Integration3. Crossplatform Integration; 4. Conclusion; 
       References; Chapter 2: Proteomics and Protein Interaction 
       in Molecular Cell Signaling Pathways; 1. Introduction; 2. 
       Experimental Techniques; 3. Computational Methods; 3.1. 
       Sequences Databases and Analysis; 3.2. Protein Feature 
       Prediction Using Protein Sequence; 3.3. Structure 
       Databases and Analysis; 3.4. Protein Families; 3.5. 
       Interactions, Pathways, and System Biology; 3.6. 
       Posttranslational Modifications; 4. Conclusion; References
505 8  Chapter 3: Understanding Specialized Ribosomal Protein 
       Functions and Associated Ribosomopathies by Navigating 
       Across Sequ ... 1. Introduction; 2. RPs and Diseases; 2.1.
       Ribosomopathies; 2.2. Cancer; 3. Specialized Functions of 
       RPs; 3.1. RP-Mediated Translational Control of Distinct 
       mRNAs, Through Interaction With IRES cis-Regulatory 
       Elements; 3.2. Posttranslational Modifications (PTMs) of 
       RPs; 3.3. RP Gene Expression; 3.4. RP Paralogs; 3.5. 
       Differential Subcellular Stoichiometry of RPs; 4. 
       Exploring RP Roles in Health and Disease by Navigating 
       Bioinformatics Resources; 4.1. RP Nomenclature 
505 8  4.2. Comparison of Human and Mouse RPs Reveals a Range of 
       Conservation Levels5. Conclusions and Future Directions; 
       References; Chapter 4: Big Data, Artificial Intelligence, 
       and Machine Learning in Neurotrauma; 1. Introduction; 2. 
       Big Data: Characteristics, Definitions, and Examples; 3. 
       Traumatic Brain Injury (TBI); 4. Big Data in TBI; 5. 
       Machine Learning; 6. Artificial Intelligence; 7. Text 
       Mining; 8. Examples of Using BD Approaches in TBI 
       Research; 9. Imaging; 10. Biochemical Markers; 11. Legacy 
       Data; 12. Future of Big Data in TBI; References 
505 8  Chapter 5: Artificial Intelligence Integration for 
       Neurodegenerative Disorders1. Introduction; 2. Wearables 
       and ML-Based Therapeutics; 3. Neurodegenerative 
       Therapeutics Through AI; 3.1. Parkinson's Disease; 3.2. 
       Seizures and Epilepsy; 3.3. Alzheimer's Disease; 3.4. 
       Amyotrophic Lateral Sclerosis; 3.5. Stroke and Spinal Cord
       Injury; 4. AI-Based Clinical Decision-Making; 5. 
       Limitations and Future Perspectives; References; Chapter 6
       : Robust Detection of Epilepsy Using Weighted-Permutation 
       Entropy: Methods and Analysis; 1. Introduction; 1.1. 
       Background; 1.2. Approach; 2. Computational Details 
520    Leveraging Biomedical and Healthcare Data: Semantics, 
       Analytics and Knowledge provides an overview of the 
       approaches used in semantic systems biology, introduces 
       novel areas of its application, and describes step-wise 
       protocols for transforming heterogeneous data into useful 
       knowledge that can influence healthcare and biomedical 
       research. Given the astronomical increase in the number of
       published reports, papers, and datasets over the last few 
       decades, the ability to curate this data has become a new 
       field of biomedical and healthcare research. This book 
       discusses big data text-based mining to better understand 
       the molecular architecture of diseases and to guide health
       care decision. It will be a valuable resource for 
       bioinformaticians and members of several areas of the 
       biomedical field who are interested in understanding more 
       about how to process and apply great amounts of data to 
       improve their research. 
588 0  Online resource; title from PDF title page (EBSCO, viewed 
       November 28, 2018). 
650  0 Medical care|xData processing. 
650  0 Proteomics. 
650  0 Protein-protein interactions. 
650  0 Nervous system|xDegeneration. 
650  7 HEALTH & FITNESS|xHolism.|2bisacsh 
650  7 HEALTH & FITNESS|xReference.|2bisacsh 
650  7 MEDICAL|xAlternative Medicine.|2bisacsh 
650  7 MEDICAL|xAtlases.|2bisacsh 
650  7 MEDICAL|xEssays.|2bisacsh 
650  7 MEDICAL|xFamily & General Practice.|2bisacsh 
650  7 MEDICAL|xHolistic Medicine.|2bisacsh 
650  7 MEDICAL|xOsteopathy.|2bisacsh 
650  7 Medical care|xData processing.|2fast|0(OCoLC)fst01013786 
650  7 Nervous system|xDegeneration.|2fast|0(OCoLC)fst01036090 
650  7 Protein-protein interactions.|2fast|0(OCoLC)fst01079705 
650  7 Proteomics.|2fast|0(OCoLC)fst01079785 
700 1  Kobeissy, Firas,|eeditor. 
700 1  Wang, Kevin K. W.,|eeditor. 
700 1  Zaraket, Fadi A.,|eeditor. 
700 1  Alawieh, Ali,|eeditor. 
776 08 |iPrint version:|tLeveraging Biomedical and Healthcare 
       Data.|bFirst edition.|dLondon : Elsevier Ltd. : Academic 
       Press, 2018|z9780128095560|z0128095563|w(OCoLC)986237293 
994    C0|bSTJ