LEADER 00000cam  22006494a 4500 
001    ocm59279754  
003    OCoLC 
005    20140802135847.0 
008    050419s2006    enka     b    001 0 eng   
010      2005011274 
016 7  101271138|2DNLM 
016    20100076777 
019    79460211 
020    0195176200|q(cloth) 
020    9780195176209|q(cloth) 
035    (OCoLC)59279754|z(OCoLC)79460211 
040    DLC|beng|cDLC|dBAKER|dC#P|dWAU|dNLM|dYDXCP|dBTCTA|dMUQ
       |dNLGGC|dUBA|dGH0|dNLC|dYUS|dILU|dIG#|dOCLCO|dOCLCF|dSTJ 
042    pcc 
049    STJP 
050 00 RA1220.3|b.J67 2006 
055 00 RA1220 .3|bJ67 2006 fol. 
055 01 RA1220.3 
060 00 2006 C-891 
060 10 QV 600|bJ83m 2006 
082 00 615.9|222 
084    44.41|2bcl 
096    QV 600|bJ83M 2006 
100 1  Josephy, P. David. 
245 10 Molecular toxicology /|cP. David Josephy, Bengt Mannervik.
250    2nd ed. 
264  1 Oxford ;|aNew York :|bOxford University Press,|c2006. 
300    xviii, 589 pages :|billustrations ;|c26 cm 
336    text|btxt|2rdacontent 
337    unmediated|bn|2rdamedia 
338    volume|bnc|2rdacarrier 
504    Includes bibliographical references and index. 
505 0  Pt. 1. Toxicity at the cellular level. Toxicology of 
       oxygen -- Covalent binding of xenobiotics to DNA and 
       protein -- DNA repair -- Chemical mutagenesis -- Oncogenes,
       tumor suppressor genes, and mutations in cancer cells -- 
       Toxicity, survival, and target theory -- Pt. 2. Enzymology
       of biotransformation. Cytochrome P450: chemical and 
       biochemical aspects -- P450: biological aspects, 
       regulation, and genetics -- Biochemistry of glutathione --
       Glutathione transferases -- Glutathione and glutathione 
       transferases: toxicological and pharmacological aspects --
       Glucuronic acid conjugation -- Arylamine N-
       acetyltransferase -- Sulfotransferase -- Pt. 3. Molecular 
       principles applied to specific toxicants. Alkylating 
       agents and 'mustards' -- Oxidative stress in the 
       erythrocyte: congenital and xenobiotic-induced 
       methemoglobinemia -- Aromatic amines and related toxic 
       compounds -- Polycyclic aromatic hydrocarbon carcinogens -
       - Acetaminophen. 
520 1  "The science of toxicology has progressed considerably 
       since Molecular Toxicology was first published in 1997. 
       New advances in biochemical and molecular biological 
       experimental techniques have helped researchers understand
       the precise effects of toxins and foreign compounds on 
       living things at the molecular, cellular, and organismal 
       levels. Breakthrough research has recently been completed 
       illuminating the human genome and the role of enzymes in 
       toxic biochemical reaction mechanisms. Toxicology now 
       covers drug metabolism and design, carcinogenesis, 
       programmed cell death, and DNA repair, among other 
       subjects. The second edition captures these and other 
       advances, and broadens its scope to address the 
       experimental science of toxicology. 
520 8  The first edition of Molecular Toxicology has become an 
       indispensable resource for graduate students in molecular 
       and biochemical toxicology courses, as well as academic 
       researchers and industrial researchers in toxicology. 
       Rigorously updated and revised, the new edition commands 
       an unrivaled authority in the field of molecular 
       toxicology."--BOOK JACKET. 
650  0 Molecular toxicology. 
650  7 Toxicologia.|2larpcal 
650  7 Biologia molecular.|2larpcal 
650  7 Molecular toxicology.|2fast|0(OCoLC)fst01024862 
650 12 Molecular Biology. 
650 12 Toxicology. 
700 1  Mannervik, Bengt. 
856 41 |3Table of contents only|uhttp://catdir.loc.gov/catdir/
       enhancements/fy0635/2005011274-t.html 
856 42 |3Publisher description|uhttp://catdir.loc.gov/catdir/
       enhancements/fy0635/2005011274-d.html 
856 42 |3Contributor biographical information|uhttp://
       catdir.loc.gov/catdir/enhancements/fy0723/2005011274-
       b.html 
994    01|bSTJ