LEADER 00000cam  2200000Ia 4500 
001    ocn593222021 
003    OCoLC 
005    20121218120616.0 
006    m        d         
007    cr cnu---unuuu 
008    100402s2010    enk     ob    001 0 eng d 
019    515541178|a600010181|a647834963|a667019385|a743432540 
035    (OCoLC)593222021 
035    (OCoLC)593222021 
035    (OCoLC)593222021|z(OCoLC)515541178|z(OCoLC)600010181
       |z(OCoLC)647834963|z(OCoLC)667019385|z(OCoLC)743432540 
037    238668|bMIL 
040    N$T|beng|cN$T|dYDX|dOCLCQ|dCDX|dIDEBK|dE7B|dOCLCQ|dCUY
       |dOCLCQ|dSTJ 
049    STJJ 
050  4 RB155.8|b.K56 2010eb 
060  4 WB 60|bK49g 2010 
072  7 PSY|x028000|2bisacsh 
082 04 615.8/95|222 
099    WORLD|aWIDE|aWEB|aE-BOOK|aR2 
100 1  Kimmelman, Jonathan. 
245 10 Gene transfer and the ethics of first-in-human research :
       |blost in translation /|cJonathan Kimmelman. 
264  1 Cambridge, UK ;|aNew York :|bCambridge University Press,
       |c2010. 
300    1 online resource (xi, 205 pages) 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
500    GMD: electronic resource. 
504    Includes bibliographical references and index. 
505 0  Introduction: gene transfer lost in translation -- What is
       gene transfer? -- Safety, values, and legitimacy: the 
       protean nature of risk in translational trials -- Taming 
       uncertainty: risk and gene-transfer clinical research -- 
       Succor or suckers? Benefit, risk, and the therapeutic 
       misconception -- Looking backward: a model value for 
       translational trials -- The chasm: the ethics of 
       initiating first-in-human clinical trials -- Tropic of 
       cancers: gene transfer in resource-poor settings -- Great 
       expectations and hard times: expectation management in 
       gene transfer -- Something in the sight adjusts itself: 
       conclusions. 
520    "Human gene transfer is widely regarded as one of the most
       promising technologies for the treatment of a variety of 
       disorders, but it presents practitioners with a variety of
       difficult ethical questions. Gene Transfer and the Ethics 
       of First-in-Human Research examines the ethical and policy
       dimensions of testing interventions in human beings for 
       the first time. The book discusses the difficult ethical 
       challenges that arise from attempting to translate 
       laboratory discoveries into clinical applications. These 
       range from which available techniques to use, when to 
       initiate human testing, questions of consent, expectation 
       in public arenas, how to define acceptable risk, and the 
       inclusion of vulnerable or disadvantaged subjects in early
       phase trials. This book is relevant to ethicists, legal 
       practitioners, policy makers, geneticists and clinicians 
       involved in clinical trials of new medical interventions"-
       -Provided by publisher. 
588    Description based on print version record. 
650  0 Gene therapy|xMoral and ethical aspects. 
650  0 Clinical trials|xMoral and ethical aspects. 
650 12 Gene Transfer Techniques|xethics. 
650 22 Human Experimentation|xethics. 
650 22 Public Policy. 
776 08 |iPrint version:|aKimmelman, Jonathan.|tGene transfer and 
       the ethics of first-in-human research.|dCambridge, UK ; 
       New York : Cambridge University Press, 2010|z9780521690843
       |w(DLC)  2009029830|w(OCoLC)428770843 
938    YBP Library Services|bYANK|n3155641 
938    Coutts Information Services|bCOUT|n11550525 
938    Ingram Digital eBook Collection|bIDEB|n238668 
938    ebrary|bEBRY|nebr10356365 
938    EBSCOhost|bEBSC|n304048 
994    01|bSTJ