| Edition |
2nd ed. |
| Description |
xviii, 589 pages : illustrations ; 26 cm |
| Bibliography |
Includes bibliographical references and index. |
| Contents |
Pt. 1. Toxicity at the cellular level. Toxicology of oxygen -- Covalent binding of xenobiotics to DNA and protein -- DNA repair -- Chemical mutagenesis -- Oncogenes, tumor suppressor genes, and mutations in cancer cells -- Toxicity, survival, and target theory -- Pt. 2. Enzymology of biotransformation. Cytochrome P450: chemical and biochemical aspects -- P450: biological aspects, regulation, and genetics -- Biochemistry of glutathione -- Glutathione transferases -- Glutathione and glutathione transferases: toxicological and pharmacological aspects -- Glucuronic acid conjugation -- Arylamine N-acetyltransferase -- Sulfotransferase -- Pt. 3. Molecular principles applied to specific toxicants. Alkylating agents and 'mustards' -- Oxidative stress in the erythrocyte: congenital and xenobiotic-induced methemoglobinemia -- Aromatic amines and related toxic compounds -- Polycyclic aromatic hydrocarbon carcinogens -- Acetaminophen. |
| Summary |
"The science of toxicology has progressed considerably since Molecular Toxicology was first published in 1997. New advances in biochemical and molecular biological experimental techniques have helped researchers understand the precise effects of toxins and foreign compounds on living things at the molecular, cellular, and organismal levels. Breakthrough research has recently been completed illuminating the human genome and the role of enzymes in toxic biochemical reaction mechanisms. Toxicology now covers drug metabolism and design, carcinogenesis, programmed cell death, and DNA repair, among other subjects. The second edition captures these and other advances, and broadens its scope to address the experimental science of toxicology. |
|
The first edition of Molecular Toxicology has become an indispensable resource for graduate students in molecular and biochemical toxicology courses, as well as academic researchers and industrial researchers in toxicology. Rigorously updated and revised, the new edition commands an unrivaled authority in the field of molecular toxicology."--BOOK JACKET. |
| Subject |
Molecular toxicology.
|
|
Molecular Biology.
|
|
Toxicology.
|
|
Toxicologia.
|
|
Biologia molecular.
|
|
Molecular toxicology. (OCoLC)fst01024862
|
| Added Author |
Mannervik, Bengt.
|
| ISBN |
0195176200 (cloth) |
|
9780195176209 (cloth) |
|
