Abstract -- 1 Introduction: Discovery & Development -- New Facet Of Industry, New Tools And Lead Optimization: 1.1 Scope And Content Of This Review -- 2 Discovery: Use Of Systems Biology For Identifying Targets -- 3 Integrative Systems Biology I -- Biochemistry:¡ Phase I Lead Discovery & Molecular Interactions -- 4 Integrative Systems Biology Ii -- Molecular Biology:¡ Phase 2 Lead Discovery & In Silico Screening -- 5. Discovery: Computational Systems Biology (Csb) In Health & And Disease I -- 6 Development:¡ In Vivo Pharmacology -- Systems Biology In Health & Disease Ii -- 7 Development: Pharmacokinetics -- Systems Biology In Health & Disease Iii -- 8 Development:¡ Multiscale Csb -- Simulation Tools -- 9 Development:¡ Drug Formulation & Delivery -- 10 Development: Preclinical Model Based Drug Development -- 11 Systems Biology: Impact On Pharma And Biotech -- 12 Acknowledgment -- 13 Bibliography.