LEADER 00000cam 22000004a 4500
001 ocm57531330
003 OCoLC
005 20071109000000.0
008 050127t20052005nyua b 001 0 eng
010 2005002585
020 0316011363
020 9780316011365
035 (OCoLC)57531330
040 DLC|beng|cDLC|dYDX|dBAKER|dVP@|dIG#|dBTCTA|dYDXCP|dCRH
042 pcc
049 GYBA
050 00 RC889|b.S52 2005
082 00 616.6/92|222
100 1 Silber, Sherman J.
245 10 How to get pregnant /|cSherman J. Silber.
250 Revised edition.
264 1 New York :|bLittle, Brown and Co.,|c[2005]
264 4 |c©2005
300 xliv, 467 pages :|billustrations ;|c24 cm
336 text|btxt|2rdacontent
337 unmediated|bn|2rdamedia
338 volume|bnc|2rdacarrier
504 Includes bibliographical references and index.
505 0 Preface. The infertility epidemic -- The importance of
understanding your biological clock -- Misleading
diagnoses of the cause of your infertility -- The simple
unexplainable effect of age -- The endometriosis myth --
The male factor and varicocele myth -- IVF and ICSI bypass
everything that can go wrong no matter what the so-called
diagnosis is -- Change in thinking since the early 1980s -
- Progress in male infertility -- Even men who don't make
sperm can have children -- Egg donation -- Can you save
your eggs for later? -- How can I be sure my baby will be
normal? -- Achieving pregnancy without the new technology
-- Where do we go for help? --
505 0 1. Getting pregnant naturally -- A brief review of female
anatomy -- How do the egg and the sperm reach the
fallopian tube? -- Ejaculation into the vagina -- Sperm
invasion -- Capacitation of sperm -- Ovulation --
Formation of the follicle -- Release of the egg --
Production of progesterone -- A review of the hormones
that control ovulation and the menstrual cycle -- How a
primitive region of the brain called the hypothalamus
controls the menstrual cycle -- Clinical importance of
GnRH release from the brain for IVF -- How do hormones
genetically prepared the egg for fertilization? --
Reduction division (meiosis) of the egg's chromosomes --
Development of the egg during growth of the follicle --
Resumption of meiosis after the LH surge -- Penetration of
the egg by a sperm -- Completion of meiosis and union of
the male and female genes -- Early development of the
fertilized egg -- Pregnancy testing -- 2. Why are humans
so infertile? -- Humans don't know when to have sex -- Why
is sex in the human so reproductively inefficient? --
Seasonal timing of sex -- Reproductive inadequacy of the
human male -- Is the environment causing the human sperm
count to go down? -- Monogamy and lack of sperm
competition -- Our worldwide infertility epidemic -- Human
destiny and infertility -- Infectious diseases -- What can
I do? --
505 0 3. Beating your biological clock : antral follicle counts
-- Age-related decline in a woman's fertility -- Most
infertile women were once fertile -- Where are you on your
biological clock? -- Age-related decline in fertility is
due to loss of your egg supply -- Evidence that it is your
ovary, not you -- What IVF pregnancy rates tell us about
how the ovary ages -- You can freeze your eggs (and even
your ovary) for later -- Tests for ovarian reserve -- Day
three FSH and estradiol -- Day three inhibin B level --
Clomid challenge test -- Antral follicle count -- How does
the biological clock work? -- What you were born with --
Antral follicles and your ovarian reserve -- Emergence of
the dominant single follicle during a normal ovulatory
monthly cycle -- Antral follicle count studies -- Antral
follicle count and number of eggs left in your ovary --
Antral follicle count and your age -- Antral follicle
count and your remaining years of fertility -- Is there
anything that can preserve the declining follicle pool in
your ovaries? -- Aggressive ovarian surgery can hurt your
biological clock -- Antral follicle count and older women
-- What if I already had a child but want more? -- Antral
follicle count and counseling older infertile patients --
How is a woman's endowment of eggs determined at birth? --
Summary --
505 0 4. Are we infertile? : simpler treatments -- How long does
it normally take to get pregnant and how do we know when
to look for help? -- Probability of conception per month
in fertile couples -- After what period of time does not
getting pregnant mean we're infertile? -- Proper timing of
intercourse -- Clomid (clomiphene citrate) -- Parlodel
(bromocriptine) -- Endometriosis -- What is endometriosis?
-- Drug treatment for endometriosis -- Surgery for
endometriosis, watch out! -- Surgery for blocked tubes and
pelvic scarring -- Conclusions -- 5. Figuring out what's
wrong : tests on the female -- History and physical --
Irregular periods and oily skin -- Too fat or too thin --
Am I ovulating? -- Basal body temperatures (BBT) -- The
monthly cycle -- Blood hormone tests -- Effect of the
brain on the hormonal cycle -- LH urine dipstick --
Ultrasound -- Ploycystic ovarian syndrome (PCOS) -- X-ray
of uterus and tubes (hysterosalpingogram) -- Laparoscopy -
- Idiopathic infertility --
505 0 6. Emotions and infertility (evidenced based) -- Popular
myths about emotions and infertility -- Does infertility
cause emotional tension, or does emotional tension cause
infertility? -- Anxiety caused by trying to time your
intercourse -- Anxiety causing you to hurry into worthless
and potentially damaging treatment -- The effect of
emotions on IVF success -- The effect of emotional calm on
your body -- IVF embryo transfer and emotions -- How to
avoid difficult embryo transfers -- Relaxation techniques
-- 7. How the male works -- The male myth -- Function of
the testicles -- Sperm production, the assembly line --
What can be done to stimulate greater sperm production? :
nothing! -- Hormone testing for men -- How sperm reach the
ejaculate -- Leaving the testicles -- What happens to
sperm in the epididymis? -- The ejaculate -- Testicular
temperature -- Sperm count -- What are sperm? -- Does
saving it up help? -- How many sperm? -- Motility of the
sperm -- The shape (morphology) of the sperm -- The semen
-- How many sperm are really necessary for a man to be
fertile? -- The hamster test and other wastes of time and
money -- Whose fault is it, the husband's or the wife's? -
- The tragedy of not treating the whole couple -- The
varicocele myth --
505 0 8. Sperm washing, intrauterine insemination (IUI), and
ovarian stimulation -- Sperm washing and IUI -- Several
methods of sperm washing -- Intrauterine insemination
(IUI) of washed sperm -- Ovarian stimulation with
gonadotropins -- Lupron (or GnRH agonist) to prevent
premature LH surge -- How are HMG and FSH (gonadotropins)
made? -- Monitoring HMG or FSH treatment and timing when
to give HCG -- Indications and directions for using HMG --
Progesterone injections -- Using birth control pills for
timing the cycle -- Comparison of the different
stimulation protocols and drugs -- Recombinant FSH versus
menopausal gonadotropins -- Step-up and step-down
protocols -- Minidose lupron -- GnRH antagonist protocols
-- Ovarian stimulation for timed intercourse or IUI versus
ovarian stimulation for IVF -- Hyperstimulation syndrome -
- No increased risk of ovarian cancer -- Multiple births
and selective reduction -- Subsequent pregnancies without
treatment -- 9. IVF (in vitro fertilization) --
Improvement in IVF pregnancy rates -- Ovarian stimulation
protocols and egg retrieval -- Egg and embryo culturing
techniques -- Intracytoplasmic sperm injection (ICSI) --
Longer culturing -- Assisted hatching -- Embryo transfer -
- Improving IVF results when there is tubal disease --
Rationale for doing IVF sooner in all cases of infertility
--
505 0 10. Step-by-step details of your IVF cycle -- Obtaining
the eggs -- Preparation of the sperm -- Culture techniques
for egg and sperm -- Culture media -- CO₂ incubator --
Culture dishes and test tubes designed to keep pH constant
when out of incubator -- Osmolality of media --
Temperature -- Protein -- Sequential culture media -- Egg
handling after retrieval from ovary -- Culturing the sperm
and eggs, and embryo transfer -- Embryo freezing -- Embryo
quality and embryo selection -- How many embryos to
transferred? -- Selective reduction -- 11. ICSI, the long-
sought solution to male infertility -- How the ICSI
technique was invented -- The meeting in Adelaide -- The
type of patients who need ICSI -- Are all types of male
infertility equally treatable with ICSI? -- The role of
the egg in normal fertilization -- Pitfalls of sperm
injection -- Avoiding damage to the egg nucleus and
spindle -- The membrane is invaginated by the injection
pipette but not broken -- Catching the sperm -- Problem of
the sperm swimming around inside the egg substance -- Step
-by-step details of the ICSI procedure -- Step 1 :
preparation of the eggs -- Step 2 : preparation of the
sperm -- Step 3 : setting up the injection dish -- Step 4
: the pipettes used for injection -- Step 5 : picking up
the sperm, breaking the tail, and injecting it into the
egg -- Step 6 : checking for fertilization and cleavage --
ICSI for male infertility versus trying to increase the
sperm count -- Obstructive azoospermia -- Nonobstructive
azoospermia -- Should ICSI be used for all IVF cycles? --
505 0 12. Will my baby by normal? -- IVF statistics and your
biological clock -- Fears about IVF offspring not related
to age -- First published studies on risk to offspring
from IVF or ICSI -- Risks associated with multiple
pregnancy -- Incidence of birth defects in ICSI and IVF
offspring -- Compared to spontaneously conceived children
: the Brussels study -- Understanding genes and
chromosomes -- An abnormal number of chromosomes causes
Down syndrome and miscarriage -- How your aging eggs
develop chromosome errors -- Is it the egg or the sperm
that is at fault? -- Chromosomal errors (aneuploidy)
versus single-gene defects -- Chromosomal translocations
and infertility -- Sex-chromosomal aneuploidies --
Severely infertile males and sex-chromosomal aneuploidy --
Chromosomal abnormalities in infertile men and women, and
in their ICSI and IVF children -- Transmission of
infertility to IVF and ICSI offspring -- Inheritance of
male infertility -- The X and the Y chromosome and male
infertility -- Inheritance of female infertility --
505 0 13. How to make sure your baby is normal : preimplantation
genetic diagnosis (PGD) -- Preimplantation embryo biopsy
with genetic diagnosis -- What is embryo biopsy? -- Is
there a risk from embryo biopsy? -- Fluorescent in situ
hybridization (FISH) and polymerase chain reaction (PCR)
to analyze the embryo -- PGD for chromosome defects -- How
defective meiosis causes Down syndrome and miscarriage --
Chromosome errors and the biological clock -- It is not
always the egg -- Embryo quality and chromosome
abnormalities -- Preventing specific genetic diseases --
PGD to prevent Down syndrome : FISH -- PGD for preventing
autosomal-recessive gene disease : cystic fibrosis -- PGD
for preventing muscular dystrophy : x-linked versus
autosomal-dominant disease -- PGD for preventing Marfan's
syndrome -- Genetic prevention of early onset Alzheimer's
-- Huntington's disease -- Predisposition toward cancer
and Rh disease -- X-linked disease -- PGD for human
leukocyte antigen (HLA) tissue typing : having a baby who
can save the life of her dying sister -- DNA
fingerprinting, single nucleotide polymorphisms (SNPs),
linked markers, and PGD -- Conclusion -- 14. Understanding
and preventing miscarriage -- Chromosome errors cause most
miscarriages -- Screening embryos for chromosomal errors -
- Aneuploidy versus chaotic mosaicism -- Preventing
miscarriage caused by chromosomal translocations -- PGD
errors -- Miscarriages not caused by chromosome errors --
Thrombophilia and folic acid -- Cervical incompetence --
Uterine abnormalities --
505 0 15. Reversing vasectomy, sperm blockage, and tubal
ligation -- Vasectomy reversal and microsurgery -- Why do
men want to reverse their vasectomy? -- The "simple"
microsurgical operation to reconnect the vas deferens --
How does vasectomy affect the ducts of the testicle? --
Length of time since vasectomy -- With modern vasectomies,
blowouts occur much sooner -- How is the epididymal
blockage bypassed? -- Recovery of fertility after
vasectomy reversal -- ICSI with retrieved sperm --
Obstruction to sperm outflow in patients who have not had
a vasectomy -- Testicle biopsy -- Microsurgical
vasoepididymostomy -- Congenital absence of the vas
deferens -- TESE-ICSI versus microsurgical
vasoepididymostomy -- Reversal of tubal ligation --
Comparison of tubal sterilization in the female to
vasectomy in the male -- Methods of blocking the tubes --
Reversal of tubal sterilization -- How the type of
sterilization affects the technique for reversal -- What
factors affect successful sterilization reversal? -- How
difficult is tubal reversal surgery for the patient? --
16. Donor sperm -- Is it my baby? -- How to select the
donor -- Frozen sperm and sperm banks -- Insemination with
donor sperm or ICSI with donor sperm -- 17. Egg donation
and gestational surrogacy -- Surrogate uterus (your mother
can have your kids for you) -- How it is done? -- Egg
donation (you can get pregnant after menopause) -- How is
it done? -- 18. The controversy over IVF, cloning, and
stem cells -- Cloning -- Exposing the hype -- How cloning
developed -- The biology of cloning -- Stem cells --
Knockout mice -- Use of stem cells to cure human disease.
650 0 Infertility|vPopular works.
650 0 Human reproductive technology|vPopular works.
856 41 |3Table of contents|uhttp://www.loc.gov/catdir/toc/ecip057
/2005002585.html
856 41 |3Table of contents
856 41 |uhttp://www.loc.gov/catdir/toc/ecip057/2005002585.html
938 Baker & Taylor|bBKTY|c27.95|d20.96|i0316011363|n0006202537
|sactive
938 Ingram|bINGR|n0316011363
938 YBP Library Services|bYANK|n2168358
994 90|bGYB
