Title |
Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets / Urs A. Boelsterli. |
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Publication Info. |
Boca Raton : CRC Press, [2007] |
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©2007 |
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Edition |
Second edition. |
Description |
399 pages : illustrations ; 25 cm |
Bibliography |
Includes bibliographical references and index. |
Contents |
Introduction -- Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology. |
Subject |
Molecular toxicology.
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Toxicology -- methods.
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Molecular Biology -- methods.
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Signal Transduction.
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Xenobiotics -- pharmacokinetics.
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Xenobiotics -- toxicity.
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ISBN |
9780849372728 |
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0849372720 |
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