| Description |
xxx, 691 pages : illustrations (chiefly color), color map ; 24 cm |
| Bibliography |
Includes bibliographical references and index. |
| Contents |
Section I Retrovirus -- Efforts to Characterize Host Response to HIV-1 Infection / Monty Montano and Paola Sebastiani -- Signaling Pathways Activated by HIV and Their Impact on Immune Responses / Katrina Gee [and others] -- Host Immune Responses in HIV Infection / Robert D. Allison and Shyam Kottilil -- HIV-1 and RNA Interference -- Examining a Complex System / Zachary A. Klase, Kuan-Teh Jeang and Fatah Kashanchi -- Section II Negative Single-Stranded RNA Virus -- Signaling Pathways Induced by Influenza Viruses / Stephan Pleschka [and others] -- Host Immune Response to Influenza Virus / Thomas M. Moran and Carolina B. López -- Signaling Pathways in the Host Cell Response to RSV Infection / Allan R. Brasier [and others] -- Protective and Pathologic Host Responses to Pulmonary Respiratory Syncytial Virus Infection / Dennis M. Lindell and Nicholas W. Lukacs -- Innate Recognition of Viral Infection and the Involvement of Autophagy / Balaji Ramanathan and Akiko Iwasaki -- VSV Infection Elicits Distinct Host Responses in the Periphery and the Brain / Carol Shoshkes Reiss -- Hantavirus Infection and Innate Immunity / Nandini Sen [and others] -- Measles Virus Captures Specific Host Machineries to Cause Immunosuppression and Disease / Bumsuk Hahm and Michael B.A. Oldstone -- Section III Positive Single-Stranded RNA Virus -- Severe Acute Respiratory Syndrome Coronavirus Induces Differential Host Gene Expression Responses Associated with Pathogenesis / Vincent T.K. Chow and W.F. Leong -- Characterization of Signaling Pathways in Cells Infected with SARS-CoV / Tetsuya Mizutani -- Impact of Filovirus Infection upon Cellular Signaling Pathways / Christopher F. Basler -- Responses to Ebola and Marburg Virus Infections / Thomas W. Geisbert, Friederike Feldmann, Joan Geisbert and Heinz Feldmann -- Host Gene Expression Triggered by West Nile Virus Infection / Janusz T. Paweska -- West Nile Virus-host Interaction: An Immunological Prospective / Raghavan Bhuvanakantham and Mah-Lee Ng -- Hepatitis C Virus (Flaviviridae): Host Immune Responses to Hepatitis C Virus / Christoph Neumann-Haefelin and Robert Thimme -- Host responses to Hepatitis C Virus Infection: Gene Expression Profiles and Viral Pathogenesis / Melanie Lambotin, Françoise Stoll-Keller and -- Thomas F. Baumert -- Differential Gene Expression in Coxsackievirus Infection and Its Effect on Viral Pathogenesis / Huifang M. Zhang [and others] -- Host Signaling Responses to Coxsackievirus Infection / Guang Gao [and others] -- Endothelial Damage Response by Dengue Virus Infection / Irene Bosch [and others] -- Molecular Pathogenesis of Human Norovirus / Ming Tan, Tibor Farkas and Xi Jiang -- Host Responses During Sindbis Virus Encephalomyelitis in Mice: New Implications for Understanding the Pathogenesis of Alphavirus Infections of the Central Nervous System / David N. Irani and Natalie A. Prow -- Section IV Double-Stranded RNA Virus -- Host Signaling Responses to Reovirus Infection / Da Pan [and others] -- Rotavirus Antagonism of the Host Innate Immune Response / John T. Patton and Mario Barro. |
| Summary |
This is the first comprehensive book on human/animal gene responses to RNA viral infections, including prevalent, emerging and re-emerging RNA viruses such as HIV, SARS-CoV, West Nile virus, influenza virus and many others. Human gene responses are reviewed by leading virologists worldwide in the following aspects: (i) the altered gene expression profiles at the transcriptional and translational levels detected with cutting-edge technologies such as cDNA microarray and proteomics; (ii) host innate and adapted immune responses to viral replication in target organs; (iii) virus-activated signal transduction pathways in cell survival, apoptosis and autophagosomal pathways; and (iv) the small interfering RNA/microRNA-mediated gene silencing pathway, a recently characterized new host defense mechanism against viral infection. Organized into 27 highly accessible and well-illustrated chapters, this volume explores state-of-the-art knowledge of the molecular mechanisms of RNA virus infection and host-virus interactions. This comprehensive compilation of the altered gene expression profiles and signal transduction pathways in host cells in response to the majority of human/animal RNA viruses opens new directions for basic and clinical research on viral pathogenesis, and also provides valuable biomarkers for researchers to select gene targets in the development of diagnostic tests and antiviral therapeutics for a number of infectious diseases. --Publisher description. |
| Subject |
RNA viruses.
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Viral genetics.
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Host-Pathogen Interactions.
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RNA Viruses -- physiology.
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RNA Viruses -- genetics.
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Gene Expression Regulation, Viral.
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RNA Interference.
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RNA viruses. (OCoLC)fst01086258
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Viral genetics. (OCoLC)fst01167607
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Genexpression. (DE-588)4020136-3
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RNS-Viren. (DE-588)4254833-0
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Genexpression.
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RNS-Viren.
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| Added Author |
Yang, Decheng.
|
| ISBN |
9789812833792 (hardcover) |
|
981283379X (hardcover) |
| Standard No. |
2881191 |
|
